A red-shifted two-photon-only caging group for three-dimensional photorelease
| Autor: | Manuela A. H. Fichte, Andreas Dreuw, Daniel A. Gacek, Erik Unger, Josef Wachtveitl, Yvonne Becker, Peter Walla, Alexander Heckel |
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| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
Chemistry General Chemistry 010402 general chemistry Ring (chemistry) Photochemistry 01 natural sciences Article 0104 chemical sciences Nucleobase Cross section (geometry) Two-photon excitation microscopy ddc:54 Group (periodic table) Veröffentlichung der TU Braunschweig Absorption (electromagnetic radiation) Excitation ddc:5 ddc:547 |
| Zdroj: | Chemical science 9 (2018) 10, p. 2797-2802. DOI 10.1039/c7sc05182d--Chem Sci--http://www.rsc.org/Publishing/Journals/SC/index.asp--http://xlink.rsc.org/?genre=journal&journal_code=SC--http://xlink.rsc.org/?genre=journal&journal_code=SC--http://www.bibliothek.uni-regensburg.de/ezeit/?2559110--2041-6539--2041-6539 |
| ISSN: | 2041-6539 2041-6520 |
| DOI: | 10.1039/c7sc05182d |
| Popis: | Based on nitrodibenzofuran (NDBF) a new photocage with higher two-photon action cross section and red-shifted absorption was developed. Due to calculations, a dimethylamino functionality (DMA) was added at ring position 7. The uncaging of nucleobases after two-photon excitation (2PE) could be visualized via double-strand displacement in a hydrogel. With this assay we achieved three-dimensional photorelease of DMA-NDBF-protected DNA orthogonal to NDBF-protected strands. While being an excellent 2P-cage, DMA-NDBF is surprisingly stable under visible-light one-photon excitation (1PE). This case of excitation-specific photochemistry enhances the scope of orthogonal photoregulation. |
| Databáze: | OpenAIRE |
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