Radiation therapy for early glottic carcinoma (T1N0M0): the final results of prospective randomized study concerning radiation field
| Autor: | Matayoshi Y, Masashi Chatani, Teruki Teshima, Norie Masaki, Toshihiko Inoue |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Oncology Glottis medicine.medical_specialty Time Factors medicine.medical_treatment Disease-Free Survival Japan Actuarial Analysis Cause of Death Internal medicine otorhinolaryngologic diseases Humans Medicine Prospective Studies Adverse effect Laryngeal Neoplasms Aged Neoplasm Staging Aged 80 and over Chi-Square Distribution business.industry Carcinoma Radiotherapy Dosage Middle Aged respiratory system Radiation therapy Glottic cancer Treatment interruption Female Radiology business |
| Zdroj: | Japanese jornal of Head and Neck Cancer. 22:127-130 |
| ISSN: | 1883-9878 0911-4335 |
| DOI: | 10.5981/jjhnc1974.22.127 |
| Popis: | To investigate the effect of radiation field on the local control of early glottic carcinoma by prospective randomized study.From May 1982 through February 1992, a total of 273 patients with early glottic carcinoma (T1N0M0) was treated at our department with a wedge filter technique using a shell to improve the dose distribution and immobilization during radiotherapy with 4 MV X-ray. Patients were randomly allocated to either treatment group A (radiation field size: 5 x 5 cm) or B (6 x 6 cm) using bilateral parallel opposed portals. Total radiation dose administered was 60 Gy in 30 fractions over a 6-week period.The 5-year recurrence-free survival rates were 88% in groups A and B (no significant difference). Minor chronic complication such as persistent arytenoid edema lasting more than 6 months or benign polypoid lesion of vocal cord was more frequently observed in group B (23%) than in group A (17%) (p = 0.038) while acute mucosal reaction and skin reaction showed no significant differences.A small field (5 x 5 cm) with an appropriate angle of wedge filter and shell fixing device is recommended to avoid adverse effect with keeping local control of early glottic carcinoma. |
| Databáze: | OpenAIRE |
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