Synthesis, anti-inflammatory, antiplatelet and in silico evaluations of (E)-3-(3-(2,3-dihydro-3-methyl-2-oxo-3H-benzoxazole-6-yl)-1-phenyl-1H-pyrazole-4-yl)acrylamides
| Autor: | SERDAR ÜNLÜ, TÜRKİZ GÜRSEL, HASAN BOLKAN ŞİMŞEK, YEŞİM ÖZKAN, NİLÜFER NERMİN TURAN DURAL, SULTAN BAYTAŞ |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Popis: | A series of (E)-3-(3-(2,3-dihydro-3-methyl-2-oxo-3H-benzoxazole-6-yl)-1-phenyl-1H-pyrazole-4-yl)acrylamides (7a-k) were synthesized and evaluated for their in vitro inhibitory activities on COX-1 and COX-2 isoforms using a human whole blood assay as well as their antiplatelet profile against human platelet aggregation using arachidonic acid as agonists. Among the synthesized derivatives 7a-k, especially compound 7g exhibited dual anti-inflammatory and antiplatelet activity with selective COX-2 inhibition. |
| Databáze: | OpenAIRE |
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