A pharmaco-EEG study on antipsychotic drugs in healthy volunteers
| Autor: | Thomas Dierks, Werner Strik, Takami Yagyu, Toshihiko Kinoshita, Gaku Okugawa, Toshiaki Isotani, Keizo Yamada, Thomas Koenig, Satoshi Irisawa, Mitsuru Kikuchi, Masafumi Yoshimura |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Olanzapine Dibenzothiazepines Indoles Time Factors Chlorpromazine medicine.medical_treatment Isoindoles Electroencephalography Benzodiazepines Quetiapine Fumarate Reference Values Haloperidol medicine Humans Single-Blind Method Antipsychotic Pharmacology Cross-Over Studies Fourier Analysis medicine.diagnostic_test business.industry Dopamine antagonist Risperidone medicine.disease Perospirone Thiazoles Schizophrenia Anesthesia Quetiapine business Antipsychotic Agents medicine.drug |
| Zdroj: | Yoshimura, Masafumi; Koenig, Thomas; Irisawa, Satoshi; Isotani, Toshiaki; Yamada, Keizo; Kikuchi, Mitsuru; Okugawa, Gaku; Yagyu, Takami; Kinoshita, Toshihiko; Strik, Werner; Dierks, Thomas (2007). A pharmaco-EEG study on antipsychotic drugs in healthy volunteers. Psychopharmacology, 191(4), pp. 995-1004. Berlin: Springer-Verlag 10.1007/s00213-007-0737-8 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-007-0737-8 |
| Popis: | RATIONALE: Both psychotropic drugs and mental disorders have typical signatures in quantitative electroencephalography (EEG). Previous studies found that some psychotropic drugs had EEG effects opposite to the EEG effects of the mental disorders treated with these drugs (key-lock principle). OBJECTIVES: We performed a placebo-controlled pharmaco-EEG study on two conventional antipsychotics (chlorpromazine and haloperidol) and four atypical antipsychotics (olanzapine, perospirone, quetiapine, and risperidone) in healthy volunteers. We investigated differences between conventional and atypical drug effects and whether the drug effects were compatible with the key-lock principle. METHODS: Fourteen subjects underwent seven EEG recording sessions, one for each drug (dosage equivalent of 1 mg haloperidol). In a time-domain analysis, we quantified the EEG by identifying clusters of transiently stable EEG topographies (microstates). Frequency-domain analysis used absolute power across electrodes and the location of the center of gravity (centroid) of the spatial distribution of power in different frequency bands. RESULTS: Perospirone increased duration of a microstate class typically shortened in schizophrenics. Haloperidol increased mean microstate duration of all classes, increased alpha 1 and beta 1 power, and tended to shift the beta 1 centroid posterior. Quetiapine decreased alpha 1 power and shifted the centroid anterior in both alpha bands. Olanzapine shifted the centroid anterior in alpha 2 and beta 1. CONCLUSIONS: The increased microstate duration under perospirone and haloperidol was opposite to effects previously reported in schizophrenic patients, suggesting a key-lock mechanism. The opposite centroid changes induced by olanzapine and quetiapine compared to haloperidol might characterize the difference between conventional and atypical antipsychotics. |
| Databáze: | OpenAIRE |
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