A Tangled Web: Origins of Reproductive Parasitism
| Autor: | Mohammed Sayeedur Rahman, Joseph J. Gillespie, Abdu F. Azad, Kevin R. Macaluso, Victoria I. Verhoeve, Timothy P. Driscoll |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Models Molecular cytoplasmic incompatibility Liposcelis bostrychophila Bacterial Toxins 03 medical and health sciences Bacterial Proteins Genetics Animals Amino Acid Sequence parthenogenesis Rickettsia Arthropods Ecology Evolution Behavior and Systematics Phylogeny biology Obligate Host (biology) intracellular bacteria Intracellular parasite Reproduction reproductive parasitism biology.organism_classification Rickettsia felis Biological Evolution 030104 developmental biology Wolbachia Female Mobilome Cytoplasmic incompatibility Plasmids Research Article |
| Zdroj: | Genome Biology and Evolution |
| ISSN: | 1759-6653 |
| Popis: | While typically a flea parasite and opportunistic human pathogen, the presence of Rickettsia felis (strain LSU-Lb) in the non-blood-feeding, parthenogenetically reproducing booklouse, Liposcelis bostrychophila, provides a system to ascertain factors governing not only host transitions but also obligate reproductive parasitism (RP). Analysis of plasmid pLbAR, unique to R. felis str. LSU-Lb, revealed a toxin–antitoxin module with similar features to prophage-encoded toxin–antitoxin modules utilized by parasitic Wolbachia strains to induce another form of RP, cytoplasmic incompatibility, in their arthropod hosts. Curiously, multiple deubiquitinase and nuclease domains of the large (3,841 aa) pLbAR toxin, as well the entire antitoxin, facilitated the detection of an assortment of related proteins from diverse intracellular bacteria, including other reproductive parasites. Our description of these remarkable components of the intracellular mobilome, including their presence in certain arthropod genomes, lends insight on the evolution of RP, while invigorating research on parasite-mediated biocontrol of arthropod-borne viral and bacterial pathogens. |
| Databáze: | OpenAIRE |
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