Bivalent transition metal complexes of ONO donor hydrazone ligand: Synthesis, structural characterization and antimicrobial activity
| Autor: | Nilesh Govindrao Salunkhe, A. R. Yaul, Ravindra Bhaskar, Anand S. Aswar |
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| Rok vydání: | 2015 |
| Předmět: |
Antifungal Agents
Spectrophotometry Infrared Stereochemistry Chemical structure chemistry.chemical_element Zinc Ligands Medicinal chemistry Mass Spectrometry Analytical Chemistry Metal Transition metal Coordination Complexes Octahedral molecular geometry Transition Elements Moiety Instrumentation Schiff Bases Spectroscopy Bacteria Molecular Structure Ligand Fungi Hydrazones Atomic and Molecular Physics and Optics Anti-Bacterial Agents chemistry Metals visual_art visual_art.visual_art_medium Stoichiometry |
| Zdroj: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 151:621-627 |
| ISSN: | 1386-1425 |
| DOI: | 10.1016/j.saa.2015.06.121 |
| Popis: | Mononuclear transition metal complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with a new hydrazone ligand derived from pyrazine-2-carbohydrazide and 2-hydroxyacetophenone have been synthesized. The isolated complexes were characterized by elemental analysis, spectral and analytical methods including elemental analyses, IR, diffuse reflectance, (1)H-NMR, mass spectra, molar conductance, magnetic moment, ESR, XRD, TG and SEM analysis. From the elemental analyses data, the stoichiometry of the complexes was found to be 1:1 (metal:ligand) having the general formulae [M(HL)(Cl)(H2O)2], [M=Mn(II), Co(II), Ni(II) and Cu(II)] and [M(L)(H2O)], [M=Zn(II) and Cd(II)]. The molar conductance values indicate the nonelectrolytic nature of metal complexes. The IR spectral data suggest that the ligand behaves as tridentate moiety with ONO donor atoms sequence towards central metal ion. The Mn(II), Co(II), Ni(II) and Cu(II) complexes have been assigned a monomeric octahedral geometry whereas tetrahedral to Zn(II) and Cd(II) complexes. The antibacterial and antifungal activities of the ligand and its metal complexes were studied against bacterial species Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis and Streptococcus pyogenes and fungi Candida albicans, Aspergillus niger and Aspergillus clavatus. The activity data show that the metal complexes have a promising biological activity comparable with the parent ligand against all bacterial and fungal species. |
| Databáze: | OpenAIRE |
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