Chronic inflammation and increased arterial stiffness in patients with cardiac syndrome X
| Autor: | Nadia Mollichelli, Emmanouil Zouridakis, Juan Carlos Kaski, Pablo Avanzas, D. K. Nassiri, Ramón Arroyo-Espliguero, V. R. Newey |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Carotid Artery Common Internal medicine medicine.artery Cardiac syndrome X medicine Humans Common carotid artery Endothelial dysfunction Aged Microvascular Angina Ultrasonography Inflammation biology business.industry C-reactive protein Middle Aged medicine.disease Elasticity medicine.anatomical_structure Endocrinology Atheroma C-Reactive Protein Intima-media thickness Case-Control Studies Chronic Disease biology.protein Cardiology Arterial stiffness Female Vascular Resistance Endothelium Vascular Cardiology and Cardiovascular Medicine business Tunica Intima Tunica Media Biomarkers Artery |
| Zdroj: | European heart journal. 24(22) |
| ISSN: | 0195-668X |
| Popis: | Aims Endothelial dysfunction and subangiographic atheroma have been reported in patients with cardiac syndrome X (CSX) but little is known regarding chronic inflammation and reduced arterial distensibility as pathogenic mechanisms. We assessed whether markers of inflammation and arterial distensibility differ in CSX patients compared to control subjects. Methods and results We studied 30 consecutive CSX patients (mean age 57±6 years, 25 women) and 30 healthy controls (mean age 54±8 years, 25 women). High sensitivity C-reactive protein (hs-CRP) levels were significantly higher in patients with CSX compared to controls (2.6 [1.7–4.5] vs 1.5[0.7–2.7] mg/l, P =0.02). Hs-CRP levels correlated with carotid intima-media thickness (IMT) (Spearman's rho=0.51; P =0.013). CSX patients also had significantly increased mean IMT values than controls ( P |
| Databáze: | OpenAIRE |
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