Effect of Pancreatic Glucagon and Its 1-21 Fragment on Gastric Emptying in Man
| Autor: | J Christiansen, O Lawaetz, B Schjoldager |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic glucagon medicine.medical_treatment Sodium chemistry.chemical_element Sodium Chloride Glucagon Gastroenterology Random Allocation Internal medicine medicine Humans Saline Clinical Trials as Topic Meal Gastric emptying Chemistry Insulin Stomach digestive oral and skin physiology Middle Aged Peptide Fragments Endocrinology medicine.anatomical_structure Gastric Emptying Female |
| Zdroj: | Scandinavian Journal of Gastroenterology. 23:726-730 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | The effect of pancreatic glucagon (G) and its 1-21 fragment (G 1-21) on gastric emptying was studied in nine healthy volunteers. Gastric emptying of a 200-ml nutrient liquid meal was assessed during continuous infusion of physiologic saline, G, or G 1-21 in equimolar concentrations. The subjects were studied three times on separate days in randomized order. Gastric emptying was measured with a gamma camera technique. The emptying was diphasic in all studies, showing an initial plateau lasting 10-15 min followed by an exponential decline. During saline infusion the time necessary for 50% of the meal to leave the stomach was 32 +/- 4 min, compared with 30 +/- 4 min and 35 +/- 3 min during infusion of G and G 1-21, respectively. It is concluded that glucagon and its 1-21 fragment in physiologic concentrations do not seem to participate in the control of gastric emptying of a nutrient liquid meal. |
| Databáze: | OpenAIRE |
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