Epidermal growth factor receptors and prognosis in primary breast cancer
| Autor: | M. Brunet, J. C. Delarue, Catherine Andrieu, Marie-Hélène Champème, Rosette Lidereau, Kamel Hacène, Frédérique Spyratos |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty medicine.drug_class medicine.medical_treatment Mammary gland Population Breast Neoplasms Biology Breast cancer Epidermal growth factor Proto-Oncogene Proteins Internal medicine medicine Humans Epidermal growth factor receptor Neoplasm Metastasis education Aged Neoplasm Staging Retrospective Studies Univariate analysis education.field_of_study Gene Amplification Middle Aged medicine.disease ErbB Receptors medicine.anatomical_structure Endocrinology Estrogen Lymphatic Metastasis Multivariate Analysis biology.protein Hormone therapy Follow-Up Studies |
| Zdroj: | Breast Cancer Research and Treatment. 17:83-89 |
| ISSN: | 1573-7217 0167-6806 |
| Popis: | A retrospective study was performed on 109 human breast tumors stored in liquid nitrogen in order to assess the prognostic value of epidermal growth factor receptor (EGF-R) (median patient follow-up 5 years). A significant inverse relationship was observed between EGF-R and both estrogen (ER) and progesterone receptors (PR). Univariate analysis showed a trend towards a shorter metastasis-free survival both in the overall population and in node-negative patients with EGF-R positive tumors. Multivariate analysis of the overall population showed that lymph-node involvement and PR status were the only significant variables in predicting metastasis-free survival. However, in patients receiving no adjuvant treatment (hormone therapy or chemotherapy). EGF was the only significant variable in the multivariate Cox analysis. No c-erbB-1 amplification was detected in these tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink