Severely Impaired Control of Bacterial Infections in a Patient With Cystic Fibrosis Defective in Mucosal-Associated Invariant T Cells
| Autor: | T. Pincikova, Johan K. Sandberg, Markus Moll, Malin Flodström-Tullberg, Lena Hjelte, Dominic Paquin-Proulx |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pulmonary and Respiratory Medicine Immune defense Cystic Fibrosis medicine.drug_class Cell Antibiotics Mucosal associated invariant T cell Critical Care and Intensive Care Medicine Peripheral blood mononuclear cell Cystic fibrosis Mucosal-Associated Invariant T Cells Young Adult 03 medical and health sciences Fatal Outcome 0302 clinical medicine medicine Humans Respiratory system business.industry Bacterial Infections medicine.disease 030104 developmental biology medicine.anatomical_structure Impaired control Immunology Cardiology and Cardiovascular Medicine business 030215 immunology |
| Zdroj: | Chest. 153:e93-e96 |
| ISSN: | 0012-3692 |
| DOI: | 10.1016/j.chest.2018.01.020 |
| Popis: | Here we report a unique case of a patient with cystic fibrosis characterized by severely impaired control of bacterial respiratory infections. This patient's susceptibility to such infections was much worse than expected from a cystic fibrosis clinical perspective, and he died at age 22 years despite extensive efforts and massive use of antibiotics. We found that this severe condition was associated with a near-complete deficiency in circulating mucosal-associated invariant T (MAIT) cells as measured at several time points. MAIT cells are a large, recently described subset of T cells that recognize microbial riboflavin metabolites presented by the highly evolutionarily conserved MR1 molecules. The MAIT cell deficiency was specific; other T-cell subsets were intact. Even though this is only one unique case, the findings lend significant support to the emerging role of MAIT cells in mucosal immune defense and suggest that MAIT cells may significantly modify the clinical phenotype of respiratory diseases. |
| Databáze: | OpenAIRE |
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