Variation in the SHC1 gene and longevity in humans
| Autor: | Mooijaart, S P, van Heemst, D, Schreuder, J, van Gerwen, S, Beekman, M, Brandt, B W, Slagboom, P Eline, Westendorp, R G, Group, 'Long Life' Study |
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| Přispěvatelé: | Preventive Dentistry |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Aging Candidate gene Src Homology 2 Domain-Containing Transforming Protein 1 media_common.quotation_subject Longevity Physiology Biology Biochemistry Endocrinology Gene Frequency Polymorphism (computer science) Valine Genetics Humans Prospective Studies Mortality Molecular Biology Allele frequency media_common Adaptor Proteins Signal Transducing Aged Netherlands Aged 80 and over Polymorphism Genetic Mortality rate Genetic Variation Cell Biology SHC1 Survival Analysis Adaptor Proteins Vesicular Transport Shc Signaling Adaptor Proteins Cohort Female Follow-Up Studies |
| Zdroj: | Mooijaart, S P, van Heemst, D, Schreuder, J, van Gerwen, S, Beekman, M, Brandt, B W, Slagboom, P E, Westendorp, R G & Group, L L S 2004, ' Variation in the SHC1 gene and longevity in humans. ', Experimental Gerontology . https://doi.org/10.1016/j.exger.2003.10.001 Experimental Gerontology. Elsevier Inc. |
| ISSN: | 0531-5565 |
| Popis: | Mice in which the p66 SHC specific region of the SHC gene is deleted live 30% longer without apparent disease. These mice have lower levels of oxidative stress and apoptosis, both of which have been linked to old age survival in man. This makes SHC1 an important candidate gene for longevity in humans. We found no variations in the p66 specific region of the SHC1 gene in 30 young and 30 extreme long-lived subjects. Thus in man, no common sequence variations occur in p66 specific region of the SHC1 gene. In two independent cohorts of respectively 730 and 563 subjects aged 85 and over, we tested the only known non-synonymous polymorphism, Met 410 Val, for association with longevity using a prospective follow-up design. In the first cohort, we found increasing valine allele frequency in three strata of increasing age at death (2.8–5.2%). Moreover, compared to Met/Met carriers, mortality rate was a factor of 0.71 (95% CI 0.45–1.13) reduced for Met/Val carriers in the combined cohorts, with similar risk estimates in both cohorts. Low valine allele frequency resulted, however, in low power to detect statistical significance. These data suggest that an association between the Met 410 Val polymorphism and longevity in humans may exist. |
| Databáze: | OpenAIRE |
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