Metabolism and disposition of 1,4,7,8-tetrachlorodibenzo p-dioxin in rats
| Autor: | C. Wiener, Janice K. Huwe, Gerald L. Larsen, Vernon J. Feil |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Polychlorinated Dibenzodioxins Environmental Engineering Health Toxicology and Mutagenesis Urine Rats Sprague-Dawley Excretion Feces Pharmacokinetics Animals Environmental Chemistry Toxicokinetics heterocyclic compounds Chemistry Public Health Environmental and Occupational Health General Medicine General Chemistry Metabolism Pollution Rats Congener Biochemistry Body Burden Environmental Pollutants Glucuronide Half-Life |
| Zdroj: | Chemosphere. 37:1885-1893 |
| ISSN: | 0045-6535 |
| Popis: | Metabolism studies of 1,4,7,8-tetrachlorodibenzo p -dioxin (TCDD), a relatively nontoxic dioxin congener, were undertaken to gain a better understanding of mammalian metabolism of dioxins without the problems associated with the use of the most toxic congener, 2,3,7,8-TCDD. 14 C-1,4,7,8-TCDD was dosed to conventional and bile-cannulated rats at a level of 8 mg/kg. The 14 C was excreted almost entirely in 72 hours with the major routes of excretion feces and bile. Metabolites were identified from the feces, bile, and urine by GC-MS or negative ion FAB MS and 1 H NMR. The two major fecal metabolites were hydroxylated tetra- and triCDDs. Glucuronide and sulfate conjugates of these hydroxyl metabolites were found in the urine and bile. Minor metabolites included dichlorocatechol, dihydroxylated tetra- and triCDDs, and conjugates of these compounds. |
| Databáze: | OpenAIRE |
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