Successful prevention of cuffed hemodialysis catheter-related infection using an antibiotic lock technique by strictly catheter-restricted antibiotic lock solution method
| Autor: | Jianghua Chen, Rong Lv, Jing Yuan, Huizhen Tan, Ping Zhang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Record locking medicine.drug_class medicine.medical_treatment Antibiotics Catheters Indwelling Renal Dialysis medicine Humans Antibiotic lock Aged business.industry Heparin Cuffed Hemodialysis Catheter Hematology General Medicine Middle Aged Surgery Catheter Nephrology Anesthesia Catheter-Related Infections Cuff Kidney Failure Chronic Gentamicin Female Hemodialysis Gentamicins business medicine.drug |
| Zdroj: | Blood purification. 27(2) |
| ISSN: | 1421-9735 |
| Popis: | Background: Catheter-related infection (CRI) is associated with increased all-cause mortality and morbidity in hemodialysis patients and may be reduced by using antimicrobial lock solutions. But the safety of long-term use of antimicrobial lock still needs to be defined. Methods: Patients with a new inserted permanent tunneled cuffed hemodialysis catheter were randomly assigned to an antibiotic lock solution of gentamicin (4 mg/ml) heparin (G group) or heparin alone (H group). Results: A total of 140 patients were enrolled in this study. CRI rates were 0.06/1,000 catheter-days for the G group versus 0.67 in the H group (p = 0.014). The risk of CRI was 10.54 higher in patients with a heparin-alone locked catheter (p = 0.025) than that with gentamicin. The serum-measured gentamicin levels were very low. Conclusions: Gentamicin lock solution reduces CRI and improves catheter survival rates in hemodialysis patients. It is relatively safe in strictly catheter-restricted antibiotic lock solution therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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