Fluorinated methacrylamide chitosan hydrogel dressings enhance healing in an acute porcine wound model
| Autor: | Hang Li, Nic D. Leipzig, M. Michelle Evancho-Chapman, Pritam S. Patil, Richard L. George, Leah P. Shriver, He Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Angiogenesis Swine lcsh:Medicine Inflammation Pharmacology Chitosan 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Hydroxyproline 0302 clinical medicine medicine Animals lcsh:Science Acrylamides Wound Healing Multidisciplinary integumentary system lcsh:R Assay Hydrogels Bandages Disease Models Animal 030104 developmental biology medicine.anatomical_structure Fluorocarbon Polymers chemistry Acute Disease Wounds and Injuries lcsh:Q medicine.symptom Keratinocyte Wound healing Blood vessel |
| Zdroj: | PLoS ONE, Vol 13, Iss 9, p e0203371 (2018) |
| ISSN: | 1932-6203 |
| Popis: | Wound healing involves multiple interrelated processes required to lead to successful healing outcomes. Phagocytosis, inflammation, cell proliferation, angiogenesis, energy production, and collagen synthesis are all directly or indirectly dependent on oxygen. Along with other critical factors, such as nutrition and comorbidities, availability of oxygen is a key determinant of healing success. Previously, we have presented a novel oxygenated hydrogel material that can be made into dressings for continuous localized oxygen delivery to wounds. In this study, an acute porcine wound model was used to test the healing benefits of these oxygenated MACF (MACF + O2) hydrogel dressings compared to controls, which included commercial Derma-GelTM hydrogel dressings. Wound closure and histological analyses were performed to assess re-epithelialization, collagen synthesis, angiogenesis, and keratinocyte maturation. Results from these assays revealed that wounds treated with MACF + O2 hydrogel dressings closed faster as compared to Derma-Gel (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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