Multiple Sensory Impairment Is Associated With Increased Risk of Dementia Among Black and White Older Adults
| Autor: | Frank R. Lin, Willa D. Brenowitz, Kristine Yaffe, Allison R. Kaup |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Aging Visual acuity Epidemiology Neurodegenerative Audiology 0302 clinical medicine Risk Factors Longitudinal Studies 030212 general & internal medicine media_common Rehabilitation Hazard ratio The Journal of Gerontology: Medical Sciences Neurological Sensation Disorders Mental health Female medicine.symptom medicine.medical_specialty Hearing loss Sensory impairment media_common.quotation_subject Clinical Sciences Visual impairment Black People Sensory system White People 03 medical and health sciences Clinical Research Perception Behavioral and Social Science Acquired Cognitive Impairment medicine Humans Dementia Eye Disease and Disorders of Vision Aged business.industry Neurosciences medicine.disease United States Brain Disorders Good Health and Well Being Cognitive Aging Geriatrics and Gerontology business Gerontology 030217 neurology & neurosurgery |
| Zdroj: | The journals of gerontology. Series A, Biological sciences and medical sciences, vol 74, iss 6 |
| ISSN: | 1758-535X 1079-5006 |
| Popis: | BACKGROUND: Few studies have examined impairment in multiple senses (multisensory impairment) and risk of dementia in comparison to having a single or no sensory impairment. METHODS: We studied 1,810 black and white nondemented participants from Health, Aging, and Body Composition (Health ABC) Study aged 70–79 years at enrollment. Sensory impairment was determined at our study baseline (Year 3–5 of Health ABC) using established cut points for vision (Bailey–Lovie visual acuity and Pelli–Robson contrast sensitivity test), hearing (audiometric testing), smell (12-item Cross-Cultural Smell Identification Test), and touch (peripheral nerve function tests). Incident dementia over 10 years of follow-up was based on hospitalization records, dementia medications, or at least 1.5 SD decline in Modified Mini-Mental State Examination score (race-specific). Cox proportional hazard models with adjustment for demographics, health behaviors, and health conditions evaluated the relationship between risk of dementia and increasing number of sensory impairments. RESULTS: Sensory impairments were common: 28% had visual impairment, 35% had hearing loss, 22% had poor smell, 12% had touch insensitivity; 26% had more than two impairments, and 5.6% had more than three sensory impairments. Number of impairments was associated with risk of dementia in a graded fashion (p < .001). Compared to no sensory impairments, the adjusted hazard ratio was 1.49 (95% CI: 1.12, 1.98) for one sensory impairment, 1.91 (95% CI: 1.39, 2.63) for two sensory impairments, and 2.85 (95% CI: 1.88, 4.30) for more than three sensory impairments. CONCLUSIONS: Multisensory impairment was strongly associated with increased risk of dementia. Although, the nature of this relationship needs further investigation, sensory function assessment in multiple domains may help identify patients at high risk of dementia. |
| Databáze: | OpenAIRE |
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