Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India
| Autor: | Mohit Kumar Divakar, Sandhya Kabra, Namita Soni, Preeti Madan, Rahul C. Bhoyar, Lipi Thukral, Shantanu Sengupta, Urmila Chaudhary, Uma Sharma, Hema Gogia, Hemlata Lall, Radhakrishnan Vs, Bani Jolly, Sujeet Kumar Singh, Vinay Nandicoori, Debasis Dash, Pooja Sharma, Charles Whittaker, Partha Rakshit, Manoj Kumar Singh, Arvinden Vr, Ravindra K. Gupta, Thomas A. Mellan, Ranjeet Maurya, Kalaiarasan Ponnusamy, Meena Datta, Neha Jha, Mohamed Imran, Salwa Naushin, Vivekanand A, Rajat Ujjainiya, Priyanka Singh, Swapnil Mishra, Karthik Bharadwaj Tallapaka, Viren Sardana, Seth Flaxman, Himanshu Chauhan, Anurag Agrawal, Rajesh Pandey, Mercy Rophina, Mohammed Faruq, Sanket Kulkarni, Divya Tej Sowpati, Nitin Bhatheja, Robin Marwal, Samir Bhatt, Mahesh Shanker Dhar, Saman Fatihi, Priyanka Mehta, Vigneshwar Senthivel |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Delta medicine.medical_specialty Adolescent Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Population India Genome Viral Biology Article Young Adult Seroepidemiologic Studies Epidemiology medicine Humans Child education Phylogeny Immune Evasion Molecular Epidemiology education.field_of_study Multidisciplinary COVID-19 Outbreak Transmissibility (vibration) Reinfection Cohort Demography |
| Zdroj: | Dhar, M S, Marwal, R, Radhakrishnan, V S, Ponnusamy, K, Jolly, B, Bhoyar, R C, Sardana, V, Naushin, S, Rophina, M, Mellan, T A, Mishra, S, Whittaker, C, Fatihi, S, Datta, M, Singh, P, Sharma, U, Ujjainiya, R, Bhatheja, N, Divakar, M K, Singh, M K, Imran, M, Senthivel, V, Maurya, R, Jha, N, Mehta, P, Vivekanand, A, Sharma, P, Arvinden, V R, Chaudhary, U, Soni, N, Thukral, L, Flaxman, S, Bhatt, S, Pandey, R, Dash, D, Faruq, M, Lall, H, Gogia, H, Madan, P, Kulkarni, S, Chauhan, H, Sengupta, S, Kabra, S, Gupta, R K, Singh, S K, Agrawal, A & Rakshit, P 2021, ' Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India ', Science, vol. 374, no. 6570, pp. 995-999 . https://doi.org/10.1126/science.abj9932 Science (New York, N.Y.) |
| DOI: | 10.1126/science.abj9932 |
| Popis: | Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi. |
| Databáze: | OpenAIRE |
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