Association of Plasminogen Activator Inhibitor 1 (PAI-1) 4G/5G Polymorphism and Susceptibility to SLE in Egyptian Children and Adolescents: A Multicenter Study [Corrigendum]
| Autor: | Aly A Yousef, Faisal Y Mohamed, Naglaa F Boraey, Nagwa E Akeel, Attia A Soliman, Nevin M Waked, Mustafa IA Hashem, Hassan Shehata, Dalia S Fahmy, Ali Ismael, Lamya M Ibrahim, Mohamed AM Ibrahim, Hanan F Salem, Sherif M Yousry, Sherif F Osman, Rania A Fouad, Eman T Enan, Mohammed A Attia, Mona R Afify, Nancy MS Zeidan, Mohamed Nashat |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Inflammation Research Journal of Inflammation Research, Vol Volume 14, Pp 265-266 (2021) |
| ISSN: | 1178-7031 |
| Popis: | Plasminogen activator inhibitor-1 (PAI-1) is a key molecule residing at the nexus between thrombosis and inflammatory processes. Recently, PAI-1 and its gene expression have emerged as a potential candidate for autoimmune disorders such as SLE.To investigate whether the PAI-1 4G/5G polymorphism at position -675 could be a genetic marker for susceptibility to childhood-onset SLE and development of lupus nephritis among Egyptian children and adolescents.Three hundred fifty patients diagnosed with childhood-onset SLE and 350 well-matched healthy controls were included in this multi-center study. All subjects were genotyped for the PAI-1 promoter 4G/5G polymorphism at position -675 using PCR- restriction fragment length polymorphism (RFLP). Serum PAI-1 levels were measured by ELISA.The PAI-1 (- 675) 4G/4G genotype was more represented in c-SLE patients, as compared to the control group (38% vs 23%; OR =2.7; [95% CI: 1.47-2.9];The PAI-1 4G/5G polymorphism may confer susceptibility to childhood-onset SLE and development of lupus nephritis among Egyptian children and adolescents. Moreover, the PAI-1 4G/4G genotype and 4G allele were associated with higher PAI-1 serum levels and higher disease activity scores. |
| Databáze: | OpenAIRE |
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