Fabrication and characterisation of self-applicating heparin sodium microneedle patches
| Autor: | Mohammed Hussain Zaman, Muhammad Farhan, Aleema Tehreem Zahra, Zeeshan Ahmad, Ming Wei Chang, Israfil Kucuk, Muhammad Arshad, Saman Zafar, Ambreen Akhtar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Fabrication Microinjections Transdermal Patch Pharmaceutical Science 02 engineering and technology Administration Cutaneous Polyvinyl alcohol 03 medical and health sciences chemistry.chemical_compound fluids and secretions 0302 clinical medicine Animals Skin Transdermal chemistry.chemical_classification Heparin Chemistry Heparin sodium technology industry and agriculture Anticoagulants Polymer 021001 nanoscience & nanotechnology Needles 030220 oncology & carcinogenesis Female Sorbitol Rabbits 0210 nano-technology Biomedical engineering |
| Zdroj: | Journal of Drug Targeting. 29:60-68 |
| ISSN: | 1029-2330 1061-186X |
| DOI: | 10.1080/1061186x.2020.1795180 |
| Popis: | The aim of this study was to develop heparin sodium loaded microneedle patches using different compositions of polyvinyl alcohol polymer and sorbitol. A vacuum micromolding technique was used to fabricate microneedle patches while heparin sodium was loaded into needle tips. Physical features of patches were evaluated by measuring thickness, width, folding endurance and swelling percentage. Patches were also characterised by optical microscopy and scanning electron microscopy to determine the microneedle length and surface morphologies. A preliminary assessment of the microneedle performance was studied by examining the |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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