Acute versus Chronic Myocardial Infarction: Diagnostic Accuracy of Quantitative Native T1 and T2 Mapping versus Assessment of Edema on Standard T2-weighted Cardiovascular MR Images for Differentiation
| Autor: | Charles B. Higgins, Dennis Säring, Christine Eulenburg, Stefan Blankenberg, Christian Stehning, Enver Tahir, Kai Muellerleile, Bernhard Schnackenburg, Maxim Avanesov, Sebastian Bohnen, M Sinn, Ulf K Radunski, Joshua Wien, Gunnar K. Lund, Maythem Saeed, Gerhard Adam |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty T2 mapping Myocardial Infarction Magnetic Resonance Imaging Cine Infarction 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine Edema Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Myocardial infarction Prospective cohort study Aged Aged 80 and over medicine.diagnostic_test Receiver operating characteristic business.industry Heart Magnetic resonance imaging Middle Aged medicine.disease Cardiovascular physiology Cardiology Female medicine.symptom business |
| Zdroj: | Radiology. 285:83-91 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiol.2017162338 |
| Popis: | Purpose To analyze the diagnostic accuracy of native T1 and T2 mapping compared with visual and quantitative assessment of edema on T2-weighted cardiac magnetic resonance (MR) images to differentiate between acute and chronic myocardial infarction. Materials and Methods This study had institutional ethics committee approval. Written informed consent was obtained from 67 consecutive patients (57 years ± 12; 78% men) with a first acute myocardial infarction, who were prospectively enrolled between April 2011 and June 2015. Four serial 1.5-T MR imaging examinations were performed at 8 days ± 5, 7 weeks ± 2, 3 months ± 0.5, and 6 months ± 1.4 after infarction and included T2-weighted, native T1/T2 mapping, and late gadolinium enhancement MR imaging. Complete follow-up data were obtained in 42 patients. Regional native T1/T2 relaxation time, T2-weighted ratio, and extracellular volume were serially measured in infarcted and remote myocardium. Receiver operating characteristic (ROC) analysis was used to determine the diagnostic accuracy of the MR imaging parameters for discriminating between acute and chronic myocardial infarction. Results Native T1 of infarcted myocardium decreased from 1286 msec ± 99 at baseline to 1077 msec ± 50 at 6 months (P < .0001), whereas T2 decreased from 84 msec ± 10 to 58 msec ± 4 (P < .0001). The T2-weighted ratio decreased from 4.1 ± 1.0 to 2.4 ± 0.6 (P < .0001). Of all the MR imaging parameters obtained, native T1 and T2 yielded the best areas under the ROC curve (AUCs) of 0.975 and 0.979, respectively, for differentiating between acute and chronic myocardial infarction. Visual analysis of the presence of edema at standard T2-weighted cardiac MR imaging resulted in an inferior AUC of 0.863 (P < .01). Conclusion Native T1 and T2 of infarcted myocardium are excellent discriminators between acute and chronic myocardial infarction and are superior to all other MR imaging parameters. Online supplemental material is available for this article. |
| Databáze: | OpenAIRE |
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