Combination treatment with comprehensive cryoablation and immunotherapy in metastatic pancreatic cancer
| Autor: | Meng-Tian Liao, Jialiang Li, Jianying Zeng, Jiansheng Zuo, He Lihua, Lizhi Niu, Yuanying Yuan, Kecheng Xu, Jibing Chen |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Brachytherapy Kaplan-Meier Estimate Cryosurgery Immunotherapy Adoptive Endocrinology Combined treatment Cytokine-Induced Killer Cells Internal medicine Metastatic pancreatic cancer Internal Medicine medicine Combined Modality Therapy Humans Aged Retrospective Studies Aged 80 and over Hepatology business.industry Immunization Passive Cryoablation Retrospective cohort study Immunotherapy Dendritic Cells Middle Aged Pancreatic Neoplasms Female business |
| Zdroj: | Pancreas. 42(7) |
| ISSN: | 1536-4828 |
| Popis: | The aim of this study was to retrospectively assess the effect of comprehensive cryosurgery (ablation of intrapancreatic and extrapancreatic tumors) plus immunotherapy in metastatic pancreatic cancer.We divided 106 patients (57 men, 49 women; median age, 65 years) into the cryoimmunotherapy (31 patients), cryotherapy (36 patients), immunotherapy (17 patients), and chemotherapy groups (22 patients). Pretreatment immune function was tested in patients who underwent immunotherapy. Overall survival (OS) after diagnosis of metastatic pancreatic cancer was assessed after a 4-year follow-up.Median OS was higher in the cryoimmunotherapy (13 months) and cryotherapy groups (7 months) than in the chemotherapy group (3.5 months; both P0.001) and was higher in the cryoimmunotherapy group than in the cryotherapy (P0.05) and immunotherapy groups (5 months; P0.001). In both the cryoimmunotherapy and cryotherapy groups, median OS was higher after multiple cryoablations than after a single cryoablation (P = 0.0048 and 0.041, respectively). In both groups, the median OS was higher in patients with normal immunologic function than in those with immune dysfunction (P0.0001 and P = 0.0004, respectively).Cryoimmunotherapy significantly increased OS in metastatic pancreatic cancer. Multiple cryoablations and normal pretreatment immunologic function were associated with better prognosis. |
| Databáze: | OpenAIRE |
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