The plasmatic and salivary levels of IL-1β, IL-18 and IL-6 are associated to emotional difference during stress in young male
| Autor: | M. Pesce, M.A. De Lutiis, Raffaella Tatangelo, Grilli A, Mario Felaco, Giovanna Campagna, Alessia Rizzuto, Lorenza Speranza, Alessio Ferrone, I. La Fratta, Antonia Patruno, Sara Franceschelli |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Saliva media_common.quotation_subject Emotions Interleukin-1beta lcsh:Medicine Immune markers Anger Article Anxiety state Young Adult 03 medical and health sciences 0302 clinical medicine Humans Medicine Young adult lcsh:Science Interleukin 6 Young male media_common Multidisciplinary biology Interleukin-6 business.industry Interleukins lcsh:R Interleukin-18 Reproducibility of Results C-Reactive Protein 030104 developmental biology Immunology biology.protein Cytokines lcsh:Q Interleukin 18 business Biomarkers Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Saliva collection is considered a non-invasive method to detect inflammatory markers in response to emotional states within natural social contexts. Numerous studies have prompted an important role of cytokines in modulating distinct aspects of social and emotional behavior. The aim of this study was to investigate the reliability of plasma and saliva as investigative tools for measure some inflammatory marker levels (CRP, IL-1β, IL-18, and IL-6). At the same time, the relationships between these markers and emotional states in response to a socio-cognitive stress (Academic Exam, AE), were considered. It was demonstrated that the plasma and saliva concentrations of all immune-mediators analyzed were significantly related across the socio-cognitive stress. In addition, when there was a close correlation to AE, the anger state, the IL-1β, the IL-18 salivary and plasmatic concentrations were significantly higher, while they decreased during the AE. On the other hand, the anxiety state and the IL-6 levels significantly increased throughout the AE. The IL-1β and IL-6 were positively associated to the anger and the anxiety state, respectively. In conclusion, our data highlight that different immune markers are similarly detectable in plasma and saliva during socio-cognitive stress. Also, they could be related to different emotional responses. |
| Databáze: | OpenAIRE |
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