Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking
| Autor: | Carlo C. Campa, Giampaolo Placidi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
PtdIns(3)P
QH301-705.5 Endosome Process (engineering) Computer science Review Computational biology Endosomes Catalysis ESCRT Inorganic Chemistry commander Membrane Microdomains Rab5 Rab7 Directionality Animals Humans Biology (General) Physical and Theoretical Chemistry QD1-999 endosome Molecular Biology Lipid raft Spectroscopy lipid rafts Endosomal Sorting Complexes Required for Transport Organic Chemistry Cell Membrane Sorting Robustness (evolution) Biological Transport General Medicine Computer Science Applications Chemistry Rab11 Kinetic proofreading retromer sorting |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 11773, p 11773 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Membrane trafficking is all about time. Automation in such a biological process is crucial to ensure management and delivery of cellular cargoes with spatiotemporal precision. Shared molecular regulators and differential engagement of trafficking components improve robustness of molecular sorting. Sequential recruitment of low affinity protein complexes ensures directionality of the process and, concomitantly, serves as a kinetic proofreading mechanism to discriminate cargoes from the whole endocytosed material. This strategy helps cells to minimize losses and operating errors in membrane trafficking, thereby matching the appealed deadline. Here, we summarize the molecular pathways of molecular sorting, focusing on their timing and efficacy. We also highlight experimental procedures and genetic approaches to robustly probe these pathways, in order to guide mechanistic studies at the interface between biochemistry and quantitative biology. |
| Databáze: | OpenAIRE |
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