Physical activity is associated with lower pulsatile stress but not carotid stiffness in children
| Autor: | Ben S. Gerber, Hema Krishna, Brooks B. Gump, Kevin S. Heffernan, Wesley K. Lefferts, Natalia S. Lima |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Pulsatile flow Hemodynamics Blood Pressure Context (language use) 030204 cardiovascular system & hematology 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Internal medicine Heart rate Internal Medicine Humans Medicine 030212 general & internal medicine Child Exercise business.industry Atherosclerosis medicine.disease Pulse pressure Carotid Arteries Blood pressure medicine.anatomical_structure Pulsatile Flow Cardiology Arterial stiffness Female business Artery |
| Zdroj: | Journal of Human Hypertension. 36:263-270 |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/s41371-021-00506-7 |
| Popis: | The cardiovascular disease (CVD) process may begin early in life when accompanied by atherosclerotic risk factors. CVD risk factors in children are associated with stiffening of the large elastic arteries, a reflection of subclinical atherosclerosis. Physical activity is a preventative lifestyle strategy that may benefit arterial stiffness by attenuating the hemodynamic stress on the artery wall. This study examined the relations between physical activity, carotid pulsatile stress, and carotid stiffness in children. One hundred and forty children (9-11 yrs; 50.0% male, 57.9% African-American, 42.10% Caucasian, body mass index (BMI) 20.1 ± 4.7 kg/m2) participated in this study. Physical activity counts were measured using a wrist-worn accelerometer and averaged over 7 days. Carotid artery β-stiffness and pulse pressure (calibrated to brachial mean and diastolic pressure) were assessed as via ultrasound and tonometry, respectively. Pulsatile stress was calculated as the product of carotid pulse pressure and heart rate. Physical activity counts were correlated with pulsatile stress (r = -0.27), and BMI (r = -0.23), but were unrelated to carotid stiffness. In multivariate models, associations between physical activity counts and pulsatile stress remained (B = -1.3 [95%CI, -2.4, -0.2], β = -0.20, p < 0.05) after covariate adjustment for age, race, sex, pubertal stage, and BMI. Carotid pulsatile stress was related to regional carotid stiffness (r = 0.45, p < 0.05). These data suggest that higher levels of physical activity at young age are associated with lower hemodynamic stress in the carotid artery. Findings are discussed in the context of an inverse relationship between hemodynamic pulsatile stress and carotid stiffness in children. |
| Databáze: | OpenAIRE |
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