Clinical features of non-specific interstitial pneumonia
| Autor: | Y Yamaji, Ichizo Suemitsu, Y. Nakamura, Yuji Ohtsuki, Tadashi Kamei, Takeo Yoshinouchi, Jiro Fujita, Jiro Takahara, M. Kobayashi, Ichiro Yamadori |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Pathology Non-specific interstitial pneumonia Bronchoalveolar Lavage Gastroenterology Interstitial inflammation Adrenal Cortex Hormones Fibrosis Internal medicine medicine Humans Aged Lung medicine.diagnostic_test business.industry Middle Aged medicine.disease respiratory tract diseases Respiratory Function Tests medicine.anatomical_structure Bronchoalveolar lavage Respiratory failure Spirometry Steroid pulse Female Lung Diseases Interstitial Tomography X-Ray Computed business Infiltration (medical) |
| Zdroj: | Respiratory Medicine. 93(2):113-118 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/s0954-6111(99)90300-1 |
| Popis: | The clinical features of 24 patients with non-specific interstitial pneumonia (NIP) were evaluated. The patients consisted of seven men and 17 women, with a median age of 60 years. In seven patients, the disease was idiopathic and eight had collagen vascular diseases. Cough, dyspnoea and fever were frequently observed. The time interval between the onset of symptoms and open lung biopsy was 3 months. Mild increases of IgG, CRP, and LDH were also frequently observed. The average per cent VC was 65·1 ± 3·2% and the average P aO 2 was 71·3 ± 2·4 Torr. Bronchoalveolar lavage was done in 20 patients, and a moderate increase in lymphocytes (27·8 ± 6·7%) with a low CD4CD8 ratio (0·86 ± 0·22) was observed. Multiple patchy infiltration or diffuse interstitial shadows, located predominantly in the lower fields of both lungs were the characteristic chest CT findings. Lung biopsies in this group were characterized by varying proportions of chronic interstitial inflammation and fibrosis which was temporarily uniform. Patients were given steroid pulse therapy or oral steroids. The results were mild to marked improvements in chest roentgenographic findings and lung functions. Four patients (16·7%) died because of respiratory failure caused by NIP. This is the first report to describe clinical features of NIP since the original report by Katzenstein and Fiorelli. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect