Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer
| Autor: | Anna Kakehashi, Minoru Kato, Satoshi Tamada, Yuji Takeyama, Tatsuya Nakatani, Min Gi, Masaki Fujioka, Yasuomi Shimizu, Hideki Wanibuchi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment epithelial-mesenchymal transition steroid sulfatase Vimentin urologic and male genital diseases Cystectomy 03 medical and health sciences 0302 clinical medicine cancer-specific survival Immunology and Microbiology (miscellaneous) Steroid sulfatase Medicine Steroid sulfate Epithelial–mesenchymal transition recurrence-free survival Bladder cancer Oncogene biology business.industry Cancer General Medicine Articles medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Cancer research bladder cancer business |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Androgen signal has been recently suggested to be associated with the progression of bladder cancer. Steroid sulfatase (STS) is a steroid sulfate activation enzyme, considered to be one of the key enzymes in the androgen signaling pathway. However, the role of STS in bladder cancer has not been elucidated. The purpose of the present study was to determine the clinical and functional significance of STS in bladder cancer. Immunohistochemical analysis of surgical specimens obtained by radical cystectomy (n=114) demonstrated that overexpression of STS was associated with the invasion of bladder cancer, as evidenced by the incidence of STS-positive cancers (11.5 and 37.1% in non-muscle invasive and muscle invasive bladder cancers, respectively; P=0.003). STS-positive cancer demonstrated shorter recurrence-free survival and cancer-specific survival (P=0.0027 and 0.0030, respectively). Furthermore, knockdown of STS significantly reduced cell migration and invasion capacities of bladder cancer cells (P |
| Databáze: | OpenAIRE |
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