Neurogliaform cells dynamically decouple neuronal synchrony between brain areas

Autor:	Ece Sakalar, Thomas Klausberger, Bálint Lasztóczi
Rok vydání:	2022
Předmět:	Cerebral Cortex Mice Multidisciplinary Interneurons Pyramidal Cells Action Potentials Animals Neural Inhibition GABAergic Neurons Nerve Net CA1 Region Hippocampal Neuroglia gamma-Aminobutyric Acid
Zdroj:	Science. 377:324-328
ISSN:	1095-9203 0036-8075
Popis:	Effective communication across brain areas requires distributed neuronal networks to dynamically synchronize or decouple their ongoing activity. GABA ergic interneurons lock ensembles to network oscillations, but there remain questions regarding how synchrony is actively disengaged to allow for new communication partners. We recorded the activity of identified interneurons in the CA1 hippocampus of awake mice. Neurogliaform cells (NGFCs)—which provide GABA ergic inhibition to distal dendrites of pyramidal cells—strongly coupled their firing to those gamma oscillations synchronizing local networks with cortical inputs. Rather than strengthening such synchrony, action potentials of NGFCs decoupled pyramidal cell activity from cortical gamma oscillations but did not reduce their firing nor affect local oscillations. Thus, NGFCs regulate information transfer by temporarily disengaging the synchrony without decreasing the activity of communicating networks.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8048434dfdac00955112c6bf5e805d2 https://doi.org/10.1126/science.abo3355 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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