Rubella virus-associated uveitis: The essentiality of aqueous humor virological analysis
| Autor: | Julien Provost, Marc Labetoulle, Elise Bouthry, Oscar Haigh, Igor Leleu, Alfred Kobal, Frédéric Mouriaux, Emmanuel Barreau, Christelle Vauloup-Fellous, Antoine Rousseau |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Journal of Ophthalmology. 32:3489-3497 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/11206721221087562 |
| Popis: | Aims / background Rubella virus-associated uveitis (RVAU) classically presents with the clinical features of Fuchs uveitis syndrome (FUS). We report a series RVAU, and discuss the relevance of available diagnostic strategies, and how vaccination could potentially prevent disease. Methods We retrospectively included patients with RV-positive aqueous humor (AH) with RT-PCR and/or intraocular RV-IgG production, between January 2014 and December 2019. RV-IgG titers from AH and serum were compared with other virus-specific IgG titers (VZV and/or CMV and/or HSV-1), to determine the derived Goldmann-Witmer coefficient (GWC’). Clinical findings at presentation and during follow-up are reported, as well as the anti-RV vaccination status. Results All 13 included patients demonstrated intraocular synthesis of RV-IgG (median GWC’: 9.5; 3.2–100). RV-RNA was detected in one patient while PCR results were negative for other HSV1, VZV and CMV. The mean delay in diagnosis was 13 ± 12.6 years, with an initial presentation of FUS in only 3 patients (23%). Only four patients had been vaccinated, but all after the recommended age. Conclusion As RVAU is a pleiomorphic entity, virological analysis (RV RT-PCR and GWC’) of aqueous humor is essential to improve the diagnosis and management of this entity. Improper vaccination against RV appears to be implicated in RVAU. |
| Databáze: | OpenAIRE |
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