In vitro antimicrobial activity of orbifloxacin against Staphylococcus intermedius isolates from canine skin and ear infections
| Autor: | Christine Médaille, Florence Etoré, J.-P. Ganiere |
|---|---|
| Přispěvatelé: | Chimiothérapie Aquacole et Environnement (CAE), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Nantes, Ecole Nationale Vétérinaire de Nantes, Vebiotel - Laboratoire de Biologie Vétérinaire, Schering-Plough France |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
040301 veterinary sciences
TIME-KILL KINETIC Staphylococcus [SDV]Life Sciences [q-bio] Ear infection Pyoderma Microbial Sensitivity Tests Microbiology 0403 veterinary science 03 medical and health sciences Dogs Anti-Infective Agents Ciprofloxacin Drug Resistance Bacterial medicine DOG Animals Dog Diseases MIC STAPHYLOCOCCUS INTERMEDIUS ORBIFLOXACIN 0303 health sciences General Veterinary biology Strain (chemistry) 030306 microbiology Staphylococcus intermedius 04 agricultural and veterinary sciences OTITIS medicine.disease biology.organism_classification Antimicrobial Otitis Externa In vitro 3. Good health PYODERMA Otitis Staphylococcal Skin Infections Orbifloxacin medicine.symptom medicine.drug |
| Zdroj: | Research in Veterinary Science Research in Veterinary Science, Elsevier, 2004, 77 (1), pp.67-71. ⟨10.1016/j.rvsc.2004.02.002⟩ |
| ISSN: | 0034-5288 |
| DOI: | 10.1016/j.rvsc.2004.02.002⟩ |
| Popis: | International audience; The objective of the study was to evaluate the in vitro activity of orbifloxacin against Staphylococcus intermedius strains isolated in France from canine skin and ear infections. The minimum inhibitory concentrations (MICs) of orbifloxacin against 240 field S. intermedius isolates (69 skin and 171 ear isolates) ranged from 0.016 to 8 mg l(-1), with MIC50 and MIC90 equal to 0.5 and 1 mg l(-1), respectively. Only one strain, a pyoderma isolate was resistant (MIC = 8 mg l(-1)). Orbifloxacin was tested at different concentrations for killing rate against five isolates obtained from pyoderma cases and against a reference strain (Stapylococcus aureus ATCC(R) 29213). Orbifloxacin expressed a concentration-dependent bactericidal activity against the S. aureus reference strain, but a time-dependent bactericidal activity against S. intermedius. Orbifloxacin induced bactericidal effect against the S. intermedius strains tested with concentrations equal to or two times MIC. |
| Databáze: | OpenAIRE |
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