Genetic basis of human testicular germ cell cancer: insights from the fruitfly and mouse
| Autor: | Peter Koopman, Kate L Loveland, Catherine M. Browne, Gary R. Hime |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
endocrine system Histology Mice Transgenic Biology medicine.disease_cause Germline Pathology and Forensic Medicine Embryonal carcinoma Mice Testicular Neoplasms medicine Animals Humans Genetics Mutation Cell Biology Seminoma Neoplasms Germ Cell and Embryonal medicine.disease Phenotype Human genetics Disease Models Animal Proto-Oncogene Proteins c-kit medicine.anatomical_structure Drosophila Teratoma Germ cell |
| Zdroj: | Cell and Tissue Research. 322:5-19 |
| ISSN: | 1432-0878 0302-766X |
| DOI: | 10.1007/s00441-005-1128-2 |
| Popis: | The prevalence of tumours of the germ line is increasing in the male population. This complex disease has a complex aetiology. We examine the contribution of genetic mutations to the development of germ line tumours in this review. In particular, we concentrate on fly and mouse experimental systems in order to demonstrate that mutations in some conserved genes cause pathologies typical of certain human germ cell tumours, whereas other mutations elicit phenotypes that are unique to the experimental model. Despite these experimental systems being imperfect, we show that they are useful models of human testicular germ cell tumourigenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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