Effect of intra-abdominal bupivacaine instillation on postoperative colonic motility
| Autor: | S. Hogstrom, A Faxén, G. Wallin, G Rimbäck, J Cassuto, P O Tollesson |
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| Rok vydání: | 1986 |
| Předmět: |
Blood Glucose
Male medicine.drug_class Colon medicine.medical_treatment Double blind Double-Blind Method Laparotomy Adynamic ileus Abdomen medicine Humans Postoperative Period Bupivacaine Local anesthetic business.industry Gastroenterology digestive system diseases medicine.anatomical_structure Anesthesia Reflex Female business Gastrointestinal Motility Colonic motility medicine.drug Research Article |
| Zdroj: | Gut. 27(2) |
| ISSN: | 0017-5749 |
| Popis: | Effect of intra-abdominal instillation of a local anaesthetic, bupivacaine, on postoperative colonic adynamic ileus was studied in a double blind manner in a randomised series of patients undergoing upper laparotomy. Propulsive colonic activity was studied postoperatively with radio-opaque markers and serial abdominal radiographs. Intra-abdominal instillation of bupivacaine 2 mg/kg bw significantly shortened the period of postoperative colonic inhibition (p less than 0.01), but did not hasten colonic transit. Furthermore, bupivacaine significantly decreased the hyperglycaemic response to surgery. It is suggested that bupivacaine inhibits the inflammatory response within the bowel wall, a response which may maintain the inhibitory spinal reflexes in the postoperative period. Blood concentrations of bupivacaine were shown to be well below toxic levels and no adverse reactions were observed. |
| Databáze: | OpenAIRE |
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