Effect of Vaccinium myrtillus anthocyanosides on ischaemia reperfusion injury in hamster cheek pouch microcirculation
| Autor: | S. Bertuglia, A. Colantuoni, S. Malandrino |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty Endothelium Ischaemia-reperfusion injury Ischemia Vaccinium myrtillus Microcirculation Anthocyanins Capillary Permeability Cheek pouch Cricetinae medicine Cell Adhesion Leukocytes Animals Pharmacology biology Mesocricetus Chemistry Anatomy medicine.disease biology.organism_classification medicine.anatomical_structure Permeability (electromagnetism) Reperfusion Injury Vaccinium Myrtillus Anthocyanosides |
| Zdroj: | Pharmacological research. 31(3-4) |
| ISSN: | 1043-6618 |
| Popis: | The effects of Vaccinium myrtillus anthocyanosides (VMA) on ischaemia reperfusion injury were investigated in the hamster cheek pouch microcirculation. Ischaemia was induced by clamping the cheek pouch for 30 min followed by 30 min of reperfusion. The microvasculature was visualized by a fluorescence technique. VMA [10 mg (100 g body weight) −1 ] were orally administered for 2 and 4 weeks. The number of adhering leukocytes to venular vessel walls, the perfused capillary length, the increase in permeability, the arteriolar diameter changes were determined. Ischaemia and reperfusion were associated with increased number of leukocytes sticking to venules, decreased number of perfused capillaries, and increased permeability. VMA decreased the number of leukocytes sticking to the venular wall and preserved the capillary perfusion; the increase in permeability was significantly reduced after reperfusion. VMA saved the arteriolar tone and induced the appearance of rhythmic diameter changes of arterioles. These results demonstrate the ability of Vaccinium myrtillus anthocyanosides to reduce microvascular impairments due to ischaemia reperfusion injury, with preservation of endothelium, attenuation of leukocyte adhesion and improvement of capillary perfusion. |
| Databáze: | OpenAIRE |
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