[76Br]Bromodeoxyuridine PET in tumor-bearing animals
| Autor: | Nigel E.A. Crompton, Barbara Kaser-Hotz, U Roelcke, Peter Vontobel, Ilonka Guenther, Klaus L. Leenders, August P. Schubiger, Jean E. Ryser, Hans Blattmann, Peter Bläuenstein, Olivier Gardelle |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Radiation-Sensitizing Agents Cancer Research Pathology medicine.medical_specialty Metabolite chemistry.chemical_compound Dogs In vivo Bromide Neoplasms medicine Animals Doubling time Tissue Distribution Radiology Nuclear Medicine and imaging Volume of distribution medicine.diagnostic_test Chemistry Washout Flow Cytometry Bromodeoxyuridine Positron emission tomography Cats Biophysics Molecular Medicine Female Bromine Radioisotopes Mathematics Half-Life Tomography Emission-Computed |
| Zdroj: | Nuclear Medicine and Biology. 28:51-57 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/s0969-8051(00)00189-x |
| Popis: | 5-bromodeoxyuridine (BUdR) provides in vitro measures of tumor cell proliferation. We used positron emission tomography to study tissue and plasma kinetics of [76Br]BUdR in tumor-bearing animals. In order to account for the slow washout of the major plasma metabolite, [76Br]bromide, a mathematical correction for the distribution volume of [76Br]bromide was applied. However, following correction specific tumor tracer retention was low or even zero and did not correlate with independent measures of proliferation. The kinetic characteristics of [76Br]BUdR make this tracer unsuitable for proliferation imaging. |
| Databáze: | OpenAIRE |
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