The relapse risk of AML patients undergoing autologous transplantation correlates with the stem cell mobilizing potential

Autor:	Ilka Rüsges-Wolter, Thomas Pabst, Joëlle Raschle, Isabelle von Grünigen, Behrouz Mansouri Taleghani, Beatrice U. Mueller
Rok vydání:	2012
Předmět:	Adult Male Oncology Cancer Research medicine.medical_specialty Myeloid CD34 Antigens CD34 Kaplan-Meier Estimate Transplantation Autologous Young Adult 03 medical and health sciences 0302 clinical medicine Autologous stem-cell transplantation Recurrence Risk Factors hemic and lymphatic diseases Internal medicine medicine Humans Autologous transplantation neoplasms Hematopoietic Stem Cell Mobilization Aged Proportional Hazards Models Retrospective Studies Peripheral Blood Stem Cell Transplantation business.industry Hematology Middle Aged Prognosis medicine.disease 3. Good health Transplantation Leukemia Myeloid Acute Leukemia medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Female Stem cell business 030215 immunology
Zdroj:	Leukemia research
ISSN:	0145-2126
Popis:	Autologous stem cell transplantation (ASCT) is widely used to consolidate first remission in AML. We determined the significance of circulating CD34+ cells at the day of blood stem cell collection in 78 AML patients. Patients mobilizing more than 60,000 CD34+ cells/ml had shorter overall survival (OS; P=0.0274), shorter time to progression (TTP; P=0.0014), and a higher relapse rate (P=0.0177). High levels of CD34+ cells were an independent marker for shorter OS and TTP in a multivariate analysis. These data suggest that ASCT is associated with unfavorable outcome in AML patients with high levels of mobilized peripheral CD34+ cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7fc36b20181c11e3bbef5106976382d https://doi.org/10.1016/j.leukres.2012.05.027 Zobrazit plný text záznamu Full Text from ScienceDirect