Neuroendocrine Neoplasia in Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma) of the Lung: A Case Report and Immunohistochemistry Analysis of Eight Pulmonary MALT Lymphomas
| Autor: | Joseph F. Tomashefski, Rania Rayes, Hope Hastings, Omid Savari |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Neoplasms Carcinoid Tumor Pathology and Forensic Medicine Neoplasms Multiple Primary 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Humans Medicine Neoplasm Aged Gastrointestinal tract Lung business.industry MALT lymphoma Lymphoma B-Cell Marginal Zone medicine.disease digestive system diseases Lymphoma Lymphatic system medicine.anatomical_structure 030220 oncology & carcinogenesis Immunohistochemistry Female 030211 gastroenterology & hepatology Surgery Anatomy business Mucosa-associated lymphoid tissue |
| Zdroj: | International Journal of Surgical Pathology. 26:660-663 |
| ISSN: | 1940-2465 1066-8969 |
| Popis: | Carcinoid tumorlets are peribronchiolar proliferations of neuroendocrine cells often associated with lung scars. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a non-Hodgkin’s lymphoma that frequently involves the gastrointestinal tract but less commonly is described in the lung. Simultaneous occurrence of neuroendocrine neoplasms and MALT lymphoma is extraordinarily rare and has predominately been reported in the gastrointestinal tract. In this article, we describe the case of a 73-year-old female with coexisting pulmonary MALT lymphoma and carcinoid tumorlets of the right middle lobe. Retrospective series of 8 pulmonary MALT lymphomas are evaluated for neuroendocrine neoplasia by immunohistochemistry. No correlation between MALT lymphoma and neuroendocrine neoplasia was identified in this case series. While the concurrence of these distinctive neoplasms is most likely coincidental, the presence of a common risk factor, or one neoplasm as a risk factor for the other, deserves study of a larger group of pulmonary MALT lymphomas. |
| Databáze: | OpenAIRE |
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