High-resolution imaging of photoreceptors in healthy human eyes using an adaptive optics retinal camera
| Autor: | Maher Saleh, Mathieu Flores, M Meillat, Guillaume Debellemanière, C. Moureaux, Perle Tumahai, Bernard Delbosc |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Aging Optics and Photonics genetic structures Adolescent Visual Acuity Article 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Optical coherence tomography Ophthalmology medicine Humans Adaptive optics Child High resolution imaging Aged medicine.diagnostic_test business.industry Healthy subjects Retinal Middle Aged eye diseases Ophthalmoscopy 030104 developmental biology chemistry Ophthalmologic examination Multivariate Analysis 030221 ophthalmology & optometry Retinal Cone Photoreceptor Cells Retinal imaging Female sense organs business Cone mosaic |
| Zdroj: | Eye (London, England). 32(11) |
| ISSN: | 1476-5454 |
| Popis: | PURPOSE: To determine the effects of age on perifoveal cone density in healthy subjects using adaptive optics. METHODS: Healthy subjects of various ages were imaged using an adaptive optics retinal camera (RTX-1(®) Imagine Eyes, Orsay, France). All patients underwent a comprehensive ophthalmologic examination and retinal imaging using spectral-domain optical coherence tomography (Spectralis(®), Heidelberg Engineering, Heidelberg, Germany). Cone density together with cone spacing and cone mosaic packing were measured in the nasal and temporal area 450 µm from the fovea. A multivariate analysis was performed to determine which of the following parameters were related to a decrease in cone density: age, axial length, central macular thickness, and retrofoveal choroidal thickness. RESULTS: One hundred and sixty-seven eyes of 101 subjects aged 6–78 years were studied. Perifoveal cone density significantly decreased with age (R(2) = 0.17, p0.05). The mean coefficient of variation between fellow eyes was 3.9%. Age and axial length were related to a cone density decrease, while choroidal and retinal thicknesses did not affect cone metrics in healthy subjects. CONCLUSIONS: A moderate perifoveal cone loss occurs with age. The precise consequences of these findings on visual function should be investigated. In addition to a better understanding of normal retinal anatomy, these results could act as a comparative database for further studies on normal and diseased retinas. |
| Databáze: | OpenAIRE |
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