Glyoxalase activities in tumor and non-tumor human urogenital tissues
| Autor: | A Pennelli, Raffaele Tenaglia, Stefania Angelucci, Paolo Sacchetta, Carmine Di Ilio, Andrea Zezza |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adenoma
Adult Male Urologic Neoplasms Cancer Research medicine.medical_specialty medicine.medical_treatment Urinary Bladder Testicle Kidney Hydroxyacylglutathione hydrolase Lactoylglutathione lyase Testicular Neoplasms Reference Values Prostate Internal medicine Testis medicine Humans Urinary Tract Carcinoma Renal Cell Aged Carcinoma Transitional Cell Chemotherapy Urinary bladder biology Genitourinary system Carcinoma Lactoylglutathione Lyase Prostatic Neoplasms Middle Aged Kidney Neoplasms Seminoma medicine.anatomical_structure Endocrinology Urinary Bladder Neoplasms Oncology biology.protein Female Thiolester Hydrolases |
| Zdroj: | Cancer Letters. 96:189-193 |
| ISSN: | 0304-3835 |
| Popis: | Glyoxalase I and glyoxalase II activities have been measured in human tumor and non-tumor samples of 15 kidneys, 15 bladders, 4 testes, 2 adrenals as well as in 4 samples of prostatic adenomas. In all tissues examined glyoxalase I and glyoxalase II activity values varied widely from one patient to another. No significant difference in glyoxalase I activity between the tumor and non-tumor samples was found. When comparison was made between normal and neoplastic tissues of the same patients, glyoxalase I activity was found to be lower in tumor tissues of 10 out of 15 kidneys, and 2 out of 8 bladders and 1 out of 3 testes. A significant (P < 0.004) decrease of glyoxalase II activity was found only in tumor kidney. The possibility of using the present data to predict the relative sensitivity of human tumor tissues to glyoxalase-related chemotherapy is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect