DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy
| Autor: | David W. Melton, Ewan M. McNeil |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Genetics
DNA Repair DNA repair DNA damage Telomere Homeostasis Computational biology Base excision repair DNA repair protein XRCC4 Biology Endonucleases DNA Repair-Deficiency Disorders Protein Structure Tertiary DNA-Binding Proteins Drug Resistance Neoplasm Neoplasms Drug Discovery Mutation Humans DNA mismatch repair Survey and Summary ERCC1 DNA Repair Endonuclease Nucleotide excision repair |
| Zdroj: | McNeil, E M & Melton, D W 2012, ' DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy ', Nucleic Acids Research, vol. 40, no. 20, pp. 9990-10004 . https://doi.org/10.1093/nar/gks818 Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | The ERCC1-XPF complex is a structure-specific endonuclease essential for the repair of DNA damage by the nucleotide excision repair pathway. It is also involved in other key cellular processes, including DNA interstrand crosslink (ICL) repair and DNA double-strand break (DSB) repair. New evidence has recently emerged, increasing our understanding of its requirement in these additional roles. In this review, we focus on the protein-protein and protein-DNA interactions made by the ERCC1 and XPF proteins and discuss how these coordinate ERCC1-XPF in its various roles. In a number of different cancers, high expression of ERCC1 has been linked to a poor response to platinum-based chemotherapy. We discuss prospects for the development of DNA repair inhibitors that target the activity, stability or protein interactions of the ERCC1-XPF complex as a novel therapeutic strategy to overcome chemoresistance. |
| Databáze: | OpenAIRE |
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