Expression of CD10 in urothelial carcinoma of the bladder and its correlation with histopathological grade, pathological stage, and survival of patients

Autor:	Rajeev Sarpal, Sushil Kumar Shukla, Smita Chandra, Neena Chauhan
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty Pathology medicine.medical_treatment Urinary Bladder Targeted therapy Pathogenesis Biomarkers Tumor Carcinoma medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Urothelium Stage (cooking) Pathological business.industry General Medicine Middle Aged medicine.disease Survival Rate Urinary Bladder Neoplasms Oncology Case-Control Studies Female Neprilysin Histopathology Neoplasm Grading business Immunostaining Follow-Up Studies
Zdroj:	Journal of Cancer Research and Therapeutics. 17:887
ISSN:	0973-1482
DOI:	10.4103/jcrt.jcrt_619_18
Popis:	Background: CD10 plays a role in signal transduction pathway and regulation of cell growth apoptosis, and therefore, it has been evaluated in different malignancies. The present study was conducted to study the immunoexpression of CD10 in urothelial carcinoma and to correlate it with histological grade, pathological stage, and survival of patients. Materials and Methods: The study included 51 cases of urothelial carcinoma diagnosed on histopathology along with 50 controls having nonneoplastic urothelium. All the cases and controls were subjected to CD10 immunostaining. The CD10 expression was compared between the cases and controls and was also correlated with histological grade, pathological stage, histomorphological features, and 1-year survival. Results: The study included 78.4% of high-grade urothelial carcinoma (HGUC) and 21.6% of low-grade urothelial carcinoma. The positive score of CD10 expression was observed in 68.6% of cases, while 96% of controls observed negative immunostaining. About 90.9% of low-grade carcinoma observed score 0, while 83.7% of high grade observed positive score of 1 and 2. Although there was statistical significant difference between CD 10 score and stage of tumor, its expression did not correlate with 1-year survival of cases. Conclusion: CD10 expression increases with the grade of tumor and thus may be helpful in differentiating low grade from HGUC. Its expression also increases with stage and poor prognostic factors suggesting its possible role in pathogenesis and progression of urothelial carcinoma. CD 10 may be further analyzed for molecular targeted therapy against urothelial carcinoma.
Databáze:	OpenAIRE
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