Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course
| Autor: | Jeanette Tas, Walther N.K.A. van Mook, Rob J. J. van Gassel, Wolfgang Buhre, Otto Bekers, Rob G. H. Driessen, Fabian H. Tijssen, Marcel Koelmann, Jeanine A. Verbunt, Susanne van Santen, Zafer Geyik, Coen D.A. Stehouwer, Serge J H Heines, Iwan C. C. van der Horst, Jan-Willem E M Sels, Steven J.R. Meex, Alma M.A. Mingels, Astrid M. L. Oude Lashof, Julia L.M. Bels, Joachim E. Wildberger, Marcus L.F. Janssen, Pieter L. Kubben, Moniek A. Donkers, Ben J. M. Hermans, Mark M.G. Mulder, Sander M. J. van Kuijk, Gerry A. F. Nicolaes, Nanon F L Heijnen, Marcel C. G. van de Poll, Bas C. T. van Bussel, Chahinda Ghossein-Doha, Kim H M Walraven, Ulrich Strauch, Melanie J. Acampo-de Jong, Frank C. Bennis, Rald V M Groven, Frank van Rosmalen, Paul H. M. Savelkoul, Marcel J.H. Aries, Dennis C J J Bergmans, Ronny M. Schnabel, Thijs Delnoij |
|---|---|
| Přispěvatelé: | Intensive Care, MUMC+: MA Arts Assistenten IC (9), Surgery, Promovendi NTM, Promovendi MHN, RS: MHeNs - R3 - Neuroscience, Biomedische Technologie, RS: Carim - H01 Clinical atrial fibrillation, RS: Carim - H08 Experimental atrial fibrillation, RS: Carim - Heart, RS: Carim - B01 Blood proteins & engineering, MUMC+: DA CDL Algemeen (9), Faculteit FHML Centraal, MUMC+: DA CDL Toegelatenen (9), MUMC+: DA CDL Analytisch cluster 1K (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, MUMC+: DA CDL (5), MUMC+: DA Medische Microbiologie en Infectieziekten (5), Medische Microbiologie, RS: NUTRIM - R2 - Liver and digestive health, RS: CAPHRI - R4 - Health Inequities and Societal Participation, MUMC+: DA MMI Staf (9), MUMC+: Diagnostiek en Advies (3), RS: Carim - B06 Imaging, MUMC+: DA Beeldvorming (5), Beeldvorming, MUMC+: MA Anesthesiologie (9), MUMC+: Centrum voor Acute en Kritieke Zorg (3), Anesthesiologie, MUMC+: MA Medische Staf IC (9), MUMC+: MA Med Staf Spec Cardiologie (9), MUMC+: MA Med Staf Artsass Cardiologie (9), RS: Carim - V04 Surgical intervention, Neurochirurgie, MUMC+: MA Med Staf Spec Neurochirurgie (9), Biochemie, Cardiologie, Pulmonologie, MUMC+: MA Med Staf Spec Longziekten (9), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: MA Reumatologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Hematologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Endocrinologie (9), Interne Geneeskunde, MUMC+: MA Interne Geneeskunde (3), Revalidatiegeneeskunde, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, RS: SHE - R1 - Research (OvO), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Heelkunde (9), MUMC+: MA Intensive Care (3), MUMC+: KIO Kemta (9), Epidemiologie, RS: CAPHRI - R2 - Creating Value-Based Health Care |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
intensive & critical care medicine.medical_specialty Critical Care END-EXPIRATORY PRESSURE Critical Illness Pneumonia Viral Disease Multimodal Imaging Severity of Illness Index Cohort Studies Betacoronavirus respiratory infections ELECTRICAL-IMPEDANCE TOMOGRAPHY Intensive care Epidemiology Pandemic medicine Humans Registries Intensive care medicine Pandemics Netherlands Protocol (science) Data collection SARS-CoV-2 business.industry Intensive Care COVID-19 General Medicine Middle Aged Prognosis Respiration Artificial Cohort Etiology Medicine Female Observational study epidemiology Coronavirus Infections business Medical ethics Cohort study Declaration of Helsinki |
| Zdroj: | BMJ Open BMJ Open, Vol 10, Iss 9 (2020) BMJ Open, 10(9):040175. BMJ Publishing Group |
| ISSN: | 2044-6055 |
| Popis: | BackgroundThe course of the disease in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in mechanically ventilated patients is unknown. To unravel the clinical heterogeneity of the SARS-CoV-2 infection in these patients, we designed the prospective observational Maastricht Intensive Care COVID cohort;MaastrICCht. We incorporated serial measurements that harbour aetiological, diagnostic and predictive information. The study aims to investigate the heterogeneity of the natural course of critically ill patients with SARS-CoV-2 infection.Study populationMechanically ventilated patients admitted to the Intensive Care with SARS- CoV-2 infection.Main messageWe will collect clinical variables, vital parameters, laboratory variables, mechanical ventilator settings, chest electrical impedance tomography, electrocardiograms, echocardiography as well as other imaging modalities to assess heterogeneity of the natural course of SARS-CoV-2 infection in critically ill patients. TheMaastrICChtcohort is, also designed to foster various other studies and registries and intends to create an open-source database for investigators. Therefore, a major part of the data collection is aligned with an existing national Intensive Care data registry and two international COVID-19 data collection initiatives. Additionally, we create a flexible design, so that additional measures can be added during the ongoing study based on new knowledge obtained from the rapidly growing body of evidence.ConclusionThe spread of the COVID-19 pandemic requires the swift implementation of observational research to unravel heterogeneity of the natural course of the disease of SARS- CoV-2 infection in mechanically ventilated patients. Our design is expected to enhance aetiological, diagnostic and prognostic understanding of the disease. This paper describes the design of theMaastrICChtcohort.Strengths and limitations of this studySerial measurements that characterize the disease course of SARS-CoV-2 infection in mechanically ventilated patientsData collection and analysis according to a predefined protocolFlexible, evolving design enabling the study of multiple aspects of SARS-CoV-2 infection in mechanically ventilated patientsSingle centre, including only ICU patients |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|