Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention

Autor: Marialessia Capuano, Elisabetta Ricottini, Giuseppe Di Gioia, Fabio Mangiacapra, Ilaria Cavallari, I Colaiori, Germano Di Sciascio, Edoardo Bressi, Michele Mattia Viscusi, Antonio Creta
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
Time Factors
Neutrophils
medicine.medical_treatment
Lymphocyte
Pharmaceutical Science
Coronary Artery Disease
030204 cardiovascular system & hematology
Risk Assessment
Coronary artery disease
03 medical and health sciences
Percutaneous Coronary Intervention
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Internal medicine
Genetics
Humans
Medicine
Lymphocyte Count
Lymphocytes
Prospective Studies
cardiovascular diseases
030212 general & internal medicine
Myocardial infarction
Neutrophil to lymphocyte ratio
Adverse effect
Genetics (clinical)
Aged
business.industry
Percutaneous coronary intervention
Middle Aged
medicine.disease
Treatment Outcome
medicine.anatomical_structure
Conventional PCI
Cardiology
Molecular Medicine
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Mace
Zdroj: Journal of Cardiovascular Translational Research. 11:517-523
ISSN: 1937-5395
1937-5387
DOI: 10.1007/s12265-018-9829-6
Popis: The prognostic role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with stable coronary artery disease (CAD) is still unclear. We enrolled 500 patients undergoing elective percutaneous coronary intervention (PCI). Blood samples were drawn prior to PCI for NLR and PLR calculation. Major adverse clinical events (MACE), which included death, myocardial infarction (MI), and target vessel revascularization (TVR), were recorded up to 5 years. Patients in the higher tertile of NLR presented higher Kaplan-Meier estimates of MACE (26.0% vs. 16.9% in tertile 2 vs. 14.3% in tertile 1; p = 0.042) and death (12.0% vs 6.9% in tertile 2 vs. 4.6% in tertile 1; p = 0.040), whereas there were no significant differences in the estimates of MI and TVR. NLR in the higher tertile was an independent predictor of MACE (HR 1.65, 95% CI 1.07-2.55, p = 0.024). No significant difference was observed across tertiles of PLR. Unlike PLR, elevated pre-procedural NLR is associated with an increased risk of 5-year clinical adverse events.
Databáze: OpenAIRE
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