Alcohol use disorder and cannabis use disorder symptomatology in adolescents is associated with dysfunction in neural processing of future events
Autor: | Joseph Aloi, Patrick M. Tyler, Abraham Killanin, Karina S. Blair, Harma Meffert, Francesca M. Filbey, Stuart F. White, Alita Mobley, Soonjo Hwang, Kathleen I. Crum, Laura C. Thornton, R. James R. Blair, Kayla Pope |
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Rok vydání: | 2020 |
Předmět: |
Male
Marijuana Abuse Adolescent media_common.quotation_subject Emotions Medicine (miscellaneous) Poison control Alcohol use disorder Affect (psychology) Article 03 medical and health sciences 0302 clinical medicine Optimism Injury prevention Humans Medicine media_common Pharmacology biology business.industry Brain medicine.disease biology.organism_classification Magnetic Resonance Imaging United States 030227 psychiatry Alcoholism Psychiatry and Mental health Posterior cingulate Relative risk Female Cannabis business 030217 neurology & neurosurgery Clinical psychology |
Zdroj: | Addict Biol |
ISSN: | 1369-1600 1355-6215 |
Popis: | Two of the most commonly used substances by adolescents in the United States are cannabis and alcohol. Cannabis Use Disorder (CUD) and Alcohol Use Disorder (AUD) are associated with impairments in decision-making processes. One mechanism for impaired decision-making in these individuals is thought to be an inability to adequately represent future events during decision-making. In the current study involving 112 adolescents, we used a comparative optimism task to examine the relationship between relative severity of CUD/AUD (as indexed by the CUD/AUD Identification Tests [CUDIT/AUDIT]) and atypical function within neural systems underlying affect-based neural represenation future events. Greater CUDIT scores were negatively related to responses within subgenual anterior and posterior cingulate cortex when processing high-intensity potential future positive and negative events. There was also a particularly marked negative relationship between CUD symptoms and blood oxygen level-dependent (BOLD) responses within visual and premotor cortices to high-intensity, negatively valenced potential future events. However, AUD symptom severity was not associated with dysfunction within these brain regions. These data indicate that relative risk/severity of CUD is associated with reduced responsiveness to future high-intensity events. This may impair decision-making where future significant consequences should guide response choice. |
Databáze: | OpenAIRE |
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