Radiographical efficacy of systemic treatment for bone metastasis from renal cell carcinoma
Autor: | Motonobu Nakamura, Nobuki Furubayashi, Takahito Negishi, Naotaka Nishiyama, Hiroshi Kitamura, Dai Takamatsu, Kousuke Ieiri |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty renal cell carcinoma medicine.medical_treatment Systemic therapy Targeted therapy 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma Internal medicine Medicine bone metastasis radiographical efficacy Oncogene business.industry Bone metastasis Cancer skeletal-related event Articles systemic treatment medicine.disease Molecular medicine Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis business |
Zdroj: | Oncology Letters |
ISSN: | 1792-1082 1792-1074 |
Popis: | Enlarged bone metastasis from renal cell carcinoma (RCC) can cause skeletal-related events, and thus treatment to inhibit the growth of bone metastases is often required. Although radiotherapy for RCC bone metastases can achieve a certain degree of local control, evidence is lacking regarding the effects of systemic therapy to improve bone metastasis. The present study aimed to assess the treatment efficacy of targeted therapy and immune checkpoint inhibitors, and to determine whether systemic therapy without radiotherapy can shrink bone metastases of RCC. The present study retrospectively reviewed 44 patients with RCC with bone metastases treated via systemic therapy, including targeted therapy or immune checkpoint inhibitors. Patients were divided into two groups: Those who underwent systemic therapy with radiotherapy for bone lesions (n=29); and those who underwent systemic therapy without radiotherapy for bone lesions (n=15). The radiographical efficacy of systemic therapy and the time to progression of bone metastases were compared between groups. The overall response rate of systemic therapy with radiotherapy was 44%, and in total, 13 patients demonstrated a partial response. Only one patient (6%) had a partial response among those who were treated via systemic therapy without radiotherapy. The time to progression of bone metastasis was 9.5 and 2.1 months in patients treated with and without radiotherapy, respectively (P |
Databáze: | OpenAIRE |
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