Virucidal activity of oral care products against SARS-CoV-2 in vitro
| Autor: | Akihiko Komine, Nako Okamoto, Kazushi Yamamoto, Erika Yamaguchi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Saliva
business.product_category Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macromolecular substances Cetylpyridinium chloride Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine stomatognathic system Chlorhexidine gluconate Medicine CHX (chlorhexidine gluconate) Original Research virucidal activity Toothpaste Traditional medicine business.industry SARS-CoV-2 technology industry and agriculture 030206 dentistry In vitro delmopinol hydrochloride body regions Otorhinolaryngology chemistry 030220 oncology & carcinogenesis CPC (cetylpyridinium chloride) Surgery Oral Surgery business Viral load |
| Zdroj: | Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology |
| ISSN: | 2212-5566 2212-5558 |
| Popis: | Objective Coronavirus disease 2019 (COVID-19) caused by infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. Since reducing the amount of virus in saliva is considered to prevent broader infection, the Center for Disease Control (CDC) and American Dental Hygienists’ Association (ADHA) have recommended use of CPC- or CHX-containing oral care products before the dental procedure. However, there is no certified evidence. So, we examined inactivation of SARS-CoV-2 by oral care products in several countries in vitro. Methods 0.05 % Cetylpyridinium chloride (CPC) mouthwash, 0.05 % CPC toothpaste and 0.30 % CPC spray in Japan; 0.06 % chlorhexidine gluconate (CHX) + 0.05 % CPC mouthwash and 0.12 % CHX + 0.05 % CPC mouthwash in Europe; 0.075 % CPC mouthwash, 0.12 % CHX mouthwash, and 0.20 % delmopinol hydrochloride mouthwash in the USA; and 0.04 % CPC mouthwash in China were assessed for their virucidal activity with ASTM E1052. Results The virus was inactivated in vitro by the contact time in directions for use of all oral care products containing CPC or delmopinol hydrochloride as anticeptics. Conclusions These results suggest that these oral care products in each country may reduce the viral load in the mouth. |
| Databáze: | OpenAIRE |
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