Role of corticosteroids in distal acidification of amiloride-treated rats
| Autor: | Gerhard Malnic, M.C. Damasco, M. Ansaldo, C.P. Lantos, de Lavallaz Ms |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.medical_treatment Sodium chemistry.chemical_element pCO2 Amiloride chemistry.chemical_compound Adrenal Cortex Hormones Corticosterone Physiology (medical) Internal medicine medicine Ion secretion Animals 18-Hydroxycorticosterone Aldosterone Pharmacology Chemistry Adrenalectomy Sodium channel Rats Inbred Strains Nephrons General Medicine Carbon Dioxide Hydrogen-Ion Concentration Rats Endocrinology Glomerular Filtration Rate medicine.drug |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 70:695-700 |
| ISSN: | 1205-7541 0008-4212 |
| Popis: | The role of amiloride-dependent sodium channels in the action of adrenal cortical steroids on urine–blood [Formula: see text] (U–B [Formula: see text]) differences was studied in bicarbonate-infused and amiloride-treated adrenalectomized rats. U–B [Formula: see text] was significantly reduced by amiloride in bicarbonate-infused control rats. Adrenalectomy further reduced U–B [Formula: see text] in amiloride-treated, bicarbonate-infused rats (from 27.9 ± 1.82 mmHg in sham-operated rats to 21.3 ± 1.58 mmHg in adrenalectomized (ADX) rats) (1 mmHg = 133.322 Pa). Acute administration of corticosterone and 18-hydroxycorticosterone (18-OH-B), but not of aldosterone, caused recovery of U–B [Formula: see text] to the level of sham-operated animals treated with amiloride. Aldosterone did not affect U–B [Formula: see text] in the presence of amiloride (21.9 mmHg ADX group vs. 20.98 mmHg aldosterone group). Results are compatible with aldosterone affecting distal H ion secretion mostly by a sodium and potential difference dependent mechanism, while corticosterone and 18-OH-B should act by other mechanisms (e.g., increased luminal buffer level).Key words: distal H ion secretion, corticosteroids, amiloride, adrenalectomy, aldosterone, corticosterone, 18-hydroxycorticosterone. |
| Databáze: | OpenAIRE |
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