Investigation of acute effects of topical Alpinia officinarum (galangal) treatment in experimental contact type burns and comparison with topical silver sulfadiazine treatment
| Autor: | Kadam, Koray, Kiyan, Selahattin, Uyanikgil, Yigit, Karabey, Fatih, Cetin, Emel Oyku |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Acute effects
Inhibitor Administration Topical Gene-Expression wound healing Silver sulfadiazine medicine Animals burn Flavonoid Galangin Alpinia officinarum Skin galangal biology Traditional medicine Chemistry Honey biology.organism_classification silver sulfadiazine Rats Management Anesthesiology and Pain Medicine Wounds Alpinia Anti-Infective Agents Local Emergency Medicine Rat Surgery Burns medicine.drug Model |
| Popis: | BACKGROUND: It was aimed to determine whether Alpinia officinarum (AO) (galangal), which has been regarded to be effective on wound healing, is healing on experimental contact type burns and compare its effects with silver sulfadiazine (SSD). METHODS: Thirty-five rats were divided into five groups of seven rats each group. Superficial second degree burns were formed by contacting a 1x1 cm copper tip which was kept at 100 degrees C constant temperature to the three shaved areas on the back of rats without applying any pressure for 10 s. All groups were irrigated with a 100 cc saline solution for 2 min. Any procedure or treatment was not applied to Group I (Control). Group II (Burn Control) was only irrigated, Group III (SSD) was applied topical SSD 4 times, with 6-h intervals (at h 0, 6, 12 and 18), Group IV (Galangal) was applied topical AO 4 times, and Group V (Gel) was applied placebo topical material, used for the preparation of topical AO, 4 times. Wound healing findings were evaluated histopathologically. RESULTS: In the galangal group, it was found that collagen discoloration didn't penetrate into deep dermis compared to other groups; epidermis, hair follicles, and sebaceous glands remained protected compared to the burn control group, and there was a thicker layer of epidermis. It was found that the galangal group was the closest group to the control group histologically. In the galangal group, it was determined that the number of vessels and total hair follicles were significantly higher in the 8th h and 4th h respectively (p Ege University Scientific Research Projects Fund [2013TIP-027] This study was supported by the Ege University Scientific Research Projects Fund as project 2013TIP-027. |
| Databáze: | OpenAIRE |
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