Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major
| Autor: | Christos Pitsavos, Christine Chrysohoou, Markisia Karageorga, Dimitris Tousoulis, Constadina Cosma, Vasilios Ladis, Christodoulos Stefanadis, Constadina Aggeli, Charalambos Antoniades |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Statistics as Topic Child Welfare Vascular Cell Adhesion Molecule-1 Vasodilation Inflammation Apolipoproteins E Forearm Internal medicine medicine Humans Blood Transfusion Endothelial dysfunction Reactive hyperemia Apolipoproteins B Apolipoprotein A-I Interleukin-6 business.industry beta-Thalassemia Infant Welfare Infant Intercellular Adhesion Molecule-1 Intercellular adhesion molecule medicine.disease Cholesterol Treatment Outcome medicine.anatomical_structure Endocrinology Regional Blood Flow Child Preschool Ferritins Circulatory system Immunology Female Endothelium Vascular Inflammation Mediators medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | International Journal of Cardiology. 105:80-84 |
| ISSN: | 0167-5273 |
| Popis: | BACKGROUND: Beta-thalassemia major is associated with increased cardiovascular risk, although the underlying mechanisms remain unclear. We examined endothelial function and serum levels of inflammatory mediators in transfusion-dependent patients with beta-thalassemia major. METHODS: The study population consisted of 67 patients with homozygous beta-thalassemia major, (aged 24.6+/-0.7 years) and 71 healthy age and sex matched controls. Forearm blood flow was measured with gauge-strain plethysmography. Forearm vasodilatory response to reactive hyperemia (RH%) or to nitrate (NTG%) was expressed as the percentage change of forearm blood flow from baseline to the maximum flow during reactive hyperemia or sublingual nitroglycerin, respectively. Serum levels of interleukin 6 (IL-6), soluble vascular cell adhesion molecule (sVCAM-1) and soluble intercellular adhesion molecule (sICAM-1) were determined with ELISA. RESULTS: Patients had significantly lower levels of total cholesterol (125+/-4.5 vs. 207+/-7 mg/ml, p |
| Databáze: | OpenAIRE |
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