High prevalence of multidrug-resistant tuberculosis in Georgia
| Autor: | Tamar Kutateladze, Nino Mdivani, Natalia Volkova, Ekaterina V. Kourbatova, Carlos del Rio, Thea Jibuti, Henry M. Blumberg, Natalia Shubladze, Ekaterina Zangaladze, George Khechinashvili, Archil Salakaia |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Multivariate analysis Tuberculosis Adolescent Cross-sectional study Antitubercular Agents Multidrug-resistance Microbial Sensitivity Tests Drug resistance Georgia (Republic) Article Mycobacterium tuberculosis Young Adult Risk Factors Internal medicine Drug Resistance Bacterial Tuberculosis Multidrug-Resistant Epidemiology Prevalence medicine Humans Young adult Tuberculosis Pulmonary Aged biology business.industry Public health General Medicine Middle Aged medicine.disease biology.organism_classification Surgery Cross-Sectional Studies Infectious Diseases Female business |
| Zdroj: | International Journal of Infectious Diseases. 12(6):635-644 |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2008.03.012 |
| Popis: | Summary Background Tuberculosis (TB) has emerged as a serious public health problem in the country of Georgia. However, little or no data exist on rates and risk factors for drug-resistant TB, including multidrug-resistant (MDR)-TB, in Georgia. Objective To assess the prevalence and risk factors for drug-resistant TB. Methods A cross-sectional prospective survey of patients with suspected pulmonary TB was carried out at four sentinel sites (Tbilisi, Zugdidi, Kutaisi, and Batumi) in Georgia between January 1, 2001 and December 31, 2004. Results Among 1422 patients with suspected pulmonary TB, 996 (70.0%) were culture positive; 931/996 (93.5%) had drug susceptibility testing performed. Overall, 64.0% of patients (48.3% of new and 85.3% of retreatment cases) had positive cultures for Mycobacterium tuberculosis resistant to ≥1 first-line antituberculosis drugs. The overall prevalence of MDR-TB was 28.1% (10.5% of newly diagnosed patients and 53.1% of retreatment cases). In multivariate analysis, risk factors for MDR-TB included: being a retreatment case (prevalence ratio (PR)=5.28, 95% CI 3.95–7.07), history of injection drug use (PR=1.59, 95% CI 1.21–2.09), and female gender (PR=1.36, 95% CI 1.12–1.65). Conclusions MDR-TB has emerged as a serious public health problem in Georgia and will greatly impact TB control strategies. |
| Databáze: | OpenAIRE |
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