Photoprotective Potential of Anthocyanins Isolated from Acanthopanax divaricatus Var. albeofructus Fruits against UV Irradiation in Human Dermal Fibroblast Cells
| Autor: | Su-Yun Lyu, Won-Bong Park |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Antioxidant
medicine.medical_treatment Cyanidin Biochemistry Anthocyanins Superoxide dismutase chemistry.chemical_compound Drug Discovery medicine TBARS Acanthopanax Pharmacology chemistry.chemical_classification Reactive oxygen species biology Lipid peroxide food and beverages Articles UVA chemistry Catalase Anthocyanin biology.protein Fibroblast Molecular Medicine |
| Zdroj: | Biomolecules & Therapeutics |
| ISSN: | 1976-9148 |
| DOI: | 10.4062/biomolther.2012.20.2.201 |
| Popis: | Ultraviolet (UV) A penetrates deeply into the skin and induces the generation of reactive oxygen species (ROS) causing damage to fibroblasts, which leads to aging of the skin. However, the body has developed an antioxidant defence system against the harmful effects of ROS. Enzymes such as superoxide dismutase (SOD) and catalase (CAT) play critical roles on the removal of excess ROS in living organisms. In this study, the antioxidant activities of anthocyanins (cyanidin 3-galactoside and cyanidin 3-lathyroside) from Acanthopanax divaricatus var. albeofructus (ADA) fruits were investigated by xylenol orange, thiobarbituric acid reactive substances (TBARS), and antioxidant enzyme assay. As a result, generation of H2O2 and lipid peroxide induced by UVA-irradiation in human dermal fibroblast (HDF-N) cells was reduced by treatment of anthocyanins. Also, augmented enzyme (SOD and CAT) activities were observed in UVA-irradiated cells when treated with anthocyanin. In conclusion, the results obtained show that anthocyanins from ADA fruits are potential candidates for the protection of fibroblast against the damaging effects of UVA irradiation. Furthermore, anthocyanin may be a good candidate for antioxidant agent development. |
| Databáze: | OpenAIRE |
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