Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death
| Autor: | Lorenzo Memeo, Manaf Ali, Neetu Singh, Leroy Lowe, Lin Li, William H. Bisson, Jayadev Raju, Maria Romano, Dustin G. Brown, Rita Dornetshuber-Fleiss, Barry J. Barclay, Kannan Badri Narayanan, Simona Romano, Yon Rojanasakul, Tae-Jin Lee, A. Ivana Scovassi, Annamaria Colacci, Edward A. Ratovitski, Leandro S. D'Abronzo, Rabindra Roy, Michael J. Gonzalez Guzman, Hyun Ho Park, Jordan Woodrick, Fahd Al-Mulla, Amedeo Amedei, Clement G. Yedjou, Monica Vaccari, Qiang Shawn Cheng, Paramita M. Ghosh, Rabeah Al-Temaimi, Seo Yun Kim, Roslida Abd Hamid, Chiara Mondello, Elizabeth P. Ryan, Stefano Forte, Ranjeet Kumar Sinha, Hosni Salem, Po Sing Leung, Suidjit Luanpitpong |
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| Přispěvatelé: | Narayanan, Kannan Badri, Ali, Manaf, Barclay, Barry J, Cheng, Qiang Shawn, D'Abronzo, Leandro, Dornetshuber Fleiss, Rita, Ghosh, Paramita M, Gonzalez Guzman, Michael J, Lee, Tae Jin, Leung, Po Sing, Li, Lin, Luanpitpong, Suidjit, Ratovitski, Edward, Rojanasakul, Yon, Romano, MARIA FIAMMETTA, Romano, Simona, Sinha, Ranjeet K, Yedjou, Clement, Al Mulla, Fahd, Al Temaimi, Rabeah, Amedei, Amedeo, Brown, Dustin G, Ryan, Elizabeth P, Colacci, Annamaria, Hamid, Roslida A, Mondello, Chiara, Raju, Jayadev, Salem, Hosni K, Woodrick, Jordan, Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Kim, Seo Yun, Bisson, William H, Lowe, Leroy, Park, Hyun Ho |
| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
Programmed cell death Carcinogenesis Oncology and Carcinogenesis Review Biology medicine.disease_cause Hazardous Substances Environmental Neoplasms Homeostasi medicine Animals Humans Homeostasis 2.1 Biological and endogenous factors Oncology & Carcinogenesis Carcinogenesi Organism Carcinogen Tissue homeostasis Cancer Cell Death Animal Environmental Exposure General Medicine Carcinogens Environmental Cell biology Apoptosis Hazardous Substance Immunology Environmental Carcinogenesis Carcinogens Generic health relevance Signal transduction Human |
| Zdroj: | Carcinogenesis, vol 36 Suppl 1, iss Suppl 1 |
| ISSN: | 1460-2180 0143-3334 |
| Popis: | Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of pro-survival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of pro-apoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis. |
| Databáze: | OpenAIRE |
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