Urinary neutrophil gelatinase-associated lipocalin for diagnosis of spontaneous bacterial peritonitis
| Autor: | Soha Zaki El-Shenawy, Tamer R. Fouad, Maha M. Elsabaawy, Nabil Omar, Eman Abdelsameea, M Ashraf Eljaky |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Urinary system Peritonitis Lipocalin Gastroenterology Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Spontaneous bacterial peritonitis Lipocalin-2 Internal medicine Ascites Medicine Humans business.industry Public Health Environmental and Occupational Health Acute kidney injury Bacterial Infections Middle Aged medicine.disease Neutrophil gelatinase-associated lipocalin Infectious Diseases 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female medicine.symptom business Biomarkers |
| Zdroj: | Tropical doctor. 49(3) |
| ISSN: | 1758-1133 |
| Popis: | Cirrhotic patients with ascites are at high risk of developing spontaneous bacterial peritonitis (SBP). After exclusion of patients with acute kidney injury (AKI) or other infections, urinary neutrophil gelatinase-associated lipocalin (NGAL) levels were compared between two matched groups of Egyptian cirrhotic patients with ascites, mostly secondary to hepatitis C infection (98%). Group 1 had SBP (n = 41) and group 2 did not (n = 45). By univariate analysis, urinary-NGAL, high total bilirubin, serum creatinine, international normalised ratio and the Model of End-Stage Liver Disease (MELD) score and low platelet count were all significantly correlated with the presence of SBP, but only urinary-NGAL could independently predict development of SBP ( P = 0.001). Urinary-NGAL at a cut-off value of 1225 pg/mL, showed a sensitivity of 95% and a specificity of 76%, and is therefore a most useful tool. |
| Databáze: | OpenAIRE |
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